Sjögren's syndrome in patients with primary biliary cirrhosis

Epaminondas V. Tsianos, Jay H. Hoofnagle, Philip C. Fox, Margaret Alspaugh, E. Anthony Jones, Daniel F. Schafer, Haralampos M. Moutsopoulos

Research output: Contribution to journalArticlepeer-review

168 Scopus citations


Symptomatology and objective findings of Sjögren's syndrome were evaluated in 38 consecutive patients with primary biliary cirrhosis. Symptoms of Sjögren's syndrome were present in 18 (47.4%) patients, but were severe enough to warrant therapy in only four (10.5%). Nineteen patients consented to evaluation for Sjögren's syndrome, which included Schirmer's I test, measurement of parotid flow rate and serum autoantibodies, labial minor salivary gland biopsy and human leukocyte antigen typing. Histological changes diagnostic of Sjögren's syndrome were present in five patients (26.3%). All five patients had symptoms of Sjögren's syndrome and three had abnormal Schirmer's I tests, but none had corneal ulcerations or decreased parotid flow rates. Results of serological tests and human leukocyte antigen typing were not similar to those described in patients with primary Sjögren's syndrome but were similar to those described in patients with rheumatoid arthritis and Sjögren's syndrome associated with primary biliary cirrhosis is a form of secondary Sjögren's syndrome resembling that associated with rheumatoid arthritis.(HEPATOLOGY 1990; 11:730‐734.)

Original languageEnglish (US)
Pages (from-to)730-734
Number of pages5
Issue number5
StatePublished - May 1990
Externally publishedYes

ASJC Scopus subject areas

  • Hepatology


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