Abstract
This review explores the hypothesis that the repetitive contraction-relaxation that occurs during chronic exercise activates skeletal myocyte nuclear factor erythroid-derived 2-like 2 (Nrf2) to upregulate antioxidant enzymes. These proteins are secreted into the circulation within extracellular vesicles and taken up by remote cells, thus providing remote organs with cytoprotection against subsequent oxidative stress.
Original language | English (US) |
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Pages (from-to) | 213-222 |
Number of pages | 10 |
Journal | Exercise and Sport Sciences Reviews |
Volume | 49 |
Issue number | 3 |
DOIs | |
State | Published - 2021 |
Keywords
- Nrf2
- antioxidants
- cardiac protection
- exosomes
- extracellular vesicles
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation