Skeletal Muscle Nrf2 Contributes to Exercise-Evoked Systemic Antioxidant Defense Via Extracellular Vesicular Communication

Research output: Contribution to journalArticlepeer-review

Abstract

This review explores the hypothesis that the repetitive contraction-relaxation that occurs during chronic exercise activates skeletal myocyte nuclear factor erythroid-derived 2-like 2 (Nrf2) to upregulate antioxidant enzymes. These proteins are secreted into the circulation within extracellular vesicles and taken up by remote cells, thus providing remote organs with cytoprotection against subsequent oxidative stress.

Original languageEnglish (US)
Pages (from-to)213-222
Number of pages10
JournalExercise and Sport Sciences Reviews
Volume49
Issue number3
DOIs
StatePublished - 2021

Keywords

  • antioxidants
  • cardiac protection
  • exosomes
  • extracellular vesicles
  • Nrf2

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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