Skin-Resident Murine Dendritic Cell Subsets Promote Distinct and Opposing Antigen-Specific T Helper Cell Responses

Botond Z. Igyártó, Krystal Haley, Daniela Ortner, Aleh Bobr, Maryam Gerami-Nejad, Brian T. Edelson, Sandra M. Zurawski, Bernard Malissen, Gerard Zurawski, Judith Berman, Daniel H. Kaplan

Research output: Contribution to journalArticlepeer-review

306 Scopus citations

Abstract

Skin-resident dendritic cells (DCs) are well positioned to encounter cutaneous pathogens and are required for the initiation of adaptive immune responses. There are at least three subsets of skin DC- Langerhans cells (LC), Langerin+ dermal DCs (dDCs), and classic dDCs. Whether these subsets have distinct or redundant function in vivo is poorly understood. Using a Candida albicans skin infection model, we have shown that direct presentation of antigen by LC is necessary and sufficient for the generation of antigen-specific T helper-17 (Th17) cells but not for the generation of cytotoxic lymphocytes (CTLs). In contrast, Langerin+ dDCs are required for the generation of antigen specific CTL and Th1 cells. Langerin+ dDCs also inhibited the ability of LCs and classic DCs to promote Th17 cell responses. This work demonstrates that skin-resident DC subsets promote distinct and opposing antigen-specific responses.

Original languageEnglish (US)
Pages (from-to)260-272
Number of pages13
JournalImmunity
Volume35
Issue number2
DOIs
StatePublished - Aug 26 2011
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Skin-Resident Murine Dendritic Cell Subsets Promote Distinct and Opposing Antigen-Specific T Helper Cell Responses'. Together they form a unique fingerprint.

Cite this