SLC31 (CTR) family of copper transporters in health and disease

Heejeong Kim, Xiaobin Wu, Jaekwon Lee

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Copper is a vital mineral for many organisms, yet it is highly toxic as demonstrated by serious health concerns associated with its deficiency or excess accumulation. The SLC31 (CTR) family of copper transporters is a major gateway of copper acquisition in eukaryotes, ranging from yeast to humans. Characterization of the function, modes of action, and regulation of CTR and other molecular factors that functionally cooperate with CTR for copper transport, compartmentalization, incorporation into cuproproteins, and detoxification has revealed that organisms have evolved fascinating mechanisms for tight control of copper metabolism. This research progress further indicates the significance of copper in health and disease and opens avenues for therapeutic control of copper bioavailability and its metabolic pathways.

Original languageEnglish (US)
Pages (from-to)561-570
Number of pages10
JournalMolecular Aspects of Medicine
Volume34
Issue number2-3
DOIs
StatePublished - Apr 2013

Keywords

  • CTR
  • Cisplatin
  • Copper
  • Menkes disease
  • Metallochaperone
  • SLC31
  • Transporter
  • Wilson disease

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry

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