Small lymphocytic lymphoma in a patient with CREST syndrome

Basem M. William; Tracey Harbert; Apar K. Ganti; Philip J. Bierman

doi:10.5144/1658-3876.2011.132

Small lymphocytic lymphoma in a patient with CREST syndrome

Basem M. William, Tracey Harbert, Apar K. Ganti, Philip J. Bierman

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2 Scopus citations

Abstract

We report a case of a 61-year-old man with a history of CREST syndrome (calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) who presented for evaluation of thrombocytopenia. He had evident cervical adenopathy and lymph node biopsy showed small lympphocytic lymphoma (SLL) with evident systemic adenopathy and bone marrow involvement. The patient achieved a complete remission with FCR (fludarabine/cyclophosphamide/rituximab) chemotherapy. About 30 cases of lymphomas are reported in the literature in association with systemic sclerosis. To our knowledge, there are no reports of a small lymphocytic lymphoma (SLL) in association with limited cutaneous systemic sclerosis with classic features of the CREST syndrome.

Original language	English (US)
Pages (from-to)	132-135
Number of pages	4
Journal	Hematology/ Oncology and Stem Cell Therapy
Volume	4
Issue number	3
DOIs	https://doi.org/10.5144/1658-3876.2011.132
State	Published - 2011

ASJC Scopus subject areas

Hematology
Oncology

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10.5144/1658-3876.2011.132

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title = "Small lymphocytic lymphoma in a patient with CREST syndrome",

abstract = "We report a case of a 61-year-old man with a history of CREST syndrome (calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) who presented for evaluation of thrombocytopenia. He had evident cervical adenopathy and lymph node biopsy showed small lympphocytic lymphoma (SLL) with evident systemic adenopathy and bone marrow involvement. The patient achieved a complete remission with FCR (fludarabine/cyclophosphamide/rituximab) chemotherapy. About 30 cases of lymphomas are reported in the literature in association with systemic sclerosis. To our knowledge, there are no reports of a small lymphocytic lymphoma (SLL) in association with limited cutaneous systemic sclerosis with classic features of the CREST syndrome.",

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AU - William, Basem M.

AU - Harbert, Tracey

AU - Ganti, Apar K.

AU - Bierman, Philip J.

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AB - We report a case of a 61-year-old man with a history of CREST syndrome (calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) who presented for evaluation of thrombocytopenia. He had evident cervical adenopathy and lymph node biopsy showed small lympphocytic lymphoma (SLL) with evident systemic adenopathy and bone marrow involvement. The patient achieved a complete remission with FCR (fludarabine/cyclophosphamide/rituximab) chemotherapy. About 30 cases of lymphomas are reported in the literature in association with systemic sclerosis. To our knowledge, there are no reports of a small lymphocytic lymphoma (SLL) in association with limited cutaneous systemic sclerosis with classic features of the CREST syndrome.

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Small lymphocytic lymphoma in a patient with CREST syndrome

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