Small lymphocytic lymphoma in a patient with CREST syndrome

Basem M. William, Tracey Harbert, Apar K. Ganti, Philip J. Bierman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


We report a case of a 61-year-old man with a history of CREST syndrome (calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia) who presented for evaluation of thrombocytopenia. He had evident cervical adenopathy and lymph node biopsy showed small lympphocytic lymphoma (SLL) with evident systemic adenopathy and bone marrow involvement. The patient achieved a complete remission with FCR (fludarabine/cyclophosphamide/rituximab) chemotherapy. About 30 cases of lymphomas are reported in the literature in association with systemic sclerosis. To our knowledge, there are no reports of a small lymphocytic lymphoma (SLL) in association with limited cutaneous systemic sclerosis with classic features of the CREST syndrome.

Original languageEnglish (US)
Pages (from-to)132-135
Number of pages4
JournalHematology/ Oncology and Stem Cell Therapy
Issue number3
StatePublished - 2011

ASJC Scopus subject areas

  • Hematology
  • Oncology


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