Small molecule mimics of DFTamP1, a database designed anti-Staphylococcal peptide

Yuxiang Dong, Tamara Lushnikova, Radha M. Golla, Xiaofang Wang, Guangshun Wang

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Antimicrobial peptides (AMPs) are important templates for developing new antimicrobial agents. Previously, we developed a database filtering technology that enabled us to design a potent anti-Staphylococcal peptide DFTamP1. Using this same design approach, we now report the discovery of a new class of bis-indole diimidazolines as AMP small molecule mimics. The best compound killed multiple S. aureus clinical strains in both planktonic and biofilm forms. The compound appeared to target bacterial membranes with antimicrobial activity and membrane permeation ability similar to daptomycin.

Original languageEnglish (US)
Pages (from-to)864-869
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume25
Issue number3
DOIs
StatePublished - 2017

Keywords

  • Antimicrobial peptides
  • Chemical synthesis
  • Database filtering technology
  • Peptide mimics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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