Small RNAs meet their targets: When methylation defends miRNAs from uridylation

Guodong Ren, Xuemei Chen, Bin Yu

Research output: Contribution to journalReview article

13 Scopus citations


Small RNAs are incorporated into Argonaute protein-containing complexes to guide the silencing of target RNAs in both animals and plants. The abundance of endogenous small RNAs is precisely controlled at multiple levels including transcription, processing and Argonaute loading. In addition to these processes, 3′ end modification of small RNAs, the topic of a research area that has rapidly evolved over the last several years, adds another layer of regulation of their abundance, diversity and function. Here, we review our recent understanding of small RNA 3′ end methylation and tailing.

Original languageEnglish (US)
Pages (from-to)1099-1104
Number of pages6
JournalRNA Biology
Issue number9
StatePublished - Sep 1 2014


  • Argonaute
  • Methylation
  • Small RNA
  • Uridylation

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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