Smart electrospun nanofibers for controlled drug release: Recent advances and new perspectives

Lin Weng, Jingwei Xie

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

In biological systems, chemical molecules or ions often release upon certain conditions, at a specific location, and over a desired period of time. Electrospun nanofibers that undergo alterations in the physicochemical characteristics corresponding to environmental changes have gained considerable interest for various applications. Inspired by biological systems, therapeutic molecules have been integrated with these smart electrospun nanofi-bers, presenting activation-modulated or feedback-regulated control of drug release. Compared to other materials like smart hydrogels, environment-responsive nanofiber-based drug delivery systems are relatively new but possess incomparable advantages due to their greater permeability, which allows shorter response time and more precise control over the release rate. In this article, we review the mechanisms of various environmental parameters functioning as stimuli to tailor the release rates of smart electrospun nanofibers. We also illustrate several typical examples in specific applications. We conclude this article with a discussion on perspectives and future possibilities in.

this field.

Original languageEnglish (US)
Pages (from-to)1944-1959
Number of pages16
JournalCurrent Pharmaceutical Design
Volume21
Issue number15
DOIs
StatePublished - Jan 1 2015

Keywords

  • Controlled release
  • Drug delivery
  • Electrospinning
  • Nanofibers
  • Stimuli-responsive

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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