Smoking and microRNA dysregulation: A cancerous combination

Navneet Momi; Sukhwinder Kaur; Satyanarayana Rachagani; Apar K. Ganti; Surinder K. Batra

doi:10.1016/j.molmed.2013.10.005

Smoking and microRNA dysregulation: A cancerous combination

Navneet Momi, Sukhwinder Kaur, Satyanarayana Rachagani, Apar K. Ganti, Surinder K. Batra

Research output: Contribution to journal › Review article

43 Scopus citations

Abstract

MicroRNAs (miRNAs) are post-transcriptional gene regulators that are differentially expressed in several pathophysiological conditions including cancer. They impact the disease course by modulating an array of putative target gene(s). Interestingly, there is a strong correlation between the various miRNAs target(s) and the smoking-regulated genes in cancer. This review article provides an insight into the current status of smoking-induced miRNAs and their genetic/epigenetic regulation in smoking-associated cancers, with a major focus on lung cancer (LC). Furthermore, it discusses the role of miRNAs in smoking-mediated oncogenic events in cancer and explores the diagnostic/prognostic potential of miRNA-based biomarkers and their efficacy as therapeutic targets.

Original language	English (US)
Pages (from-to)	36-47
Number of pages	12
Journal	Trends in Molecular Medicine
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.molmed.2013.10.005
State	Published - Jan 2014

Keywords

Cancer
Diagnostic
Epigenetics
MiRNA
Signaling
Smoking

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

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10.1016/j.molmed.2013.10.005

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Cite this

Momi, N., Kaur, S., Rachagani, S., Ganti, A. K., & Batra, S. K. (2014). Smoking and microRNA dysregulation: A cancerous combination. Trends in Molecular Medicine, 20(1), 36-47. https://doi.org/10.1016/j.molmed.2013.10.005

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