Abstract
MicroRNAs (miRNAs) are post-transcriptional gene regulators that are differentially expressed in several pathophysiological conditions including cancer. They impact the disease course by modulating an array of putative target gene(s). Interestingly, there is a strong correlation between the various miRNAs target(s) and the smoking-regulated genes in cancer. This review article provides an insight into the current status of smoking-induced miRNAs and their genetic/epigenetic regulation in smoking-associated cancers, with a major focus on lung cancer (LC). Furthermore, it discusses the role of miRNAs in smoking-mediated oncogenic events in cancer and explores the diagnostic/prognostic potential of miRNA-based biomarkers and their efficacy as therapeutic targets.
Original language | English (US) |
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Pages (from-to) | 36-47 |
Number of pages | 12 |
Journal | Trends in Molecular Medicine |
Volume | 20 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2014 |
Keywords
- Cancer
- Diagnostic
- Epigenetics
- MiRNA
- Signaling
- Smoking
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology