Smoking and microRNA dysregulation: A cancerous combination

Navneet Momi; Sukhwinder Kaur; Satyanarayana Rachagani; Apar K. Ganti; Surinder K. Batra

doi:10.1016/j.molmed.2013.10.005

Smoking and microRNA dysregulation: A cancerous combination

Navneet Momi, Sukhwinder Kaur, Satyanarayana Rachagani, Apar K. Ganti, Surinder K. Batra

Research output: Contribution to journal › Review article › peer-review

65 Scopus citations

Abstract

MicroRNAs (miRNAs) are post-transcriptional gene regulators that are differentially expressed in several pathophysiological conditions including cancer. They impact the disease course by modulating an array of putative target gene(s). Interestingly, there is a strong correlation between the various miRNAs target(s) and the smoking-regulated genes in cancer. This review article provides an insight into the current status of smoking-induced miRNAs and their genetic/epigenetic regulation in smoking-associated cancers, with a major focus on lung cancer (LC). Furthermore, it discusses the role of miRNAs in smoking-mediated oncogenic events in cancer and explores the diagnostic/prognostic potential of miRNA-based biomarkers and their efficacy as therapeutic targets.

Original language	English (US)
Pages (from-to)	36-47
Number of pages	12
Journal	Trends in Molecular Medicine
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/j.molmed.2013.10.005
State	Published - Jan 2014

Keywords

Cancer
Diagnostic
Epigenetics
MiRNA
Signaling
Smoking

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

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10.1016/j.molmed.2013.10.005

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title = "Smoking and microRNA dysregulation: A cancerous combination",

abstract = "MicroRNAs (miRNAs) are post-transcriptional gene regulators that are differentially expressed in several pathophysiological conditions including cancer. They impact the disease course by modulating an array of putative target gene(s). Interestingly, there is a strong correlation between the various miRNAs target(s) and the smoking-regulated genes in cancer. This review article provides an insight into the current status of smoking-induced miRNAs and their genetic/epigenetic regulation in smoking-associated cancers, with a major focus on lung cancer (LC). Furthermore, it discusses the role of miRNAs in smoking-mediated oncogenic events in cancer and explores the diagnostic/prognostic potential of miRNA-based biomarkers and their efficacy as therapeutic targets.",

keywords = "Cancer, Diagnostic, Epigenetics, MiRNA, Signaling, Smoking",

author = "Navneet Momi and Sukhwinder Kaur and Satyanarayana Rachagani and Ganti, {Apar K.} and Batra, {Surinder K.}",

note = "Funding Information: The authors of this work are supported, in part, by grants from the National Institutes of Health (TMEN U54 CA163120, EDRN UO1 CA111294, RO1 CA131944, RO1 CA133774, SPORE P50 CA127297, RO3 CA167342, and RO1 CA78590) and VA Career Development Award.",

year = "2014",

month = jan,

doi = "10.1016/j.molmed.2013.10.005",

language = "English (US)",

volume = "20",

pages = "36--47",

journal = "Trends in Molecular Medicine",

issn = "1471-4914",

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T2 - A cancerous combination

AU - Momi, Navneet

AU - Kaur, Sukhwinder

AU - Rachagani, Satyanarayana

AU - Ganti, Apar K.

AU - Batra, Surinder K.

N1 - Funding Information: The authors of this work are supported, in part, by grants from the National Institutes of Health (TMEN U54 CA163120, EDRN UO1 CA111294, RO1 CA131944, RO1 CA133774, SPORE P50 CA127297, RO3 CA167342, and RO1 CA78590) and VA Career Development Award.

PY - 2014/1

Y1 - 2014/1

N2 - MicroRNAs (miRNAs) are post-transcriptional gene regulators that are differentially expressed in several pathophysiological conditions including cancer. They impact the disease course by modulating an array of putative target gene(s). Interestingly, there is a strong correlation between the various miRNAs target(s) and the smoking-regulated genes in cancer. This review article provides an insight into the current status of smoking-induced miRNAs and their genetic/epigenetic regulation in smoking-associated cancers, with a major focus on lung cancer (LC). Furthermore, it discusses the role of miRNAs in smoking-mediated oncogenic events in cancer and explores the diagnostic/prognostic potential of miRNA-based biomarkers and their efficacy as therapeutic targets.

AB - MicroRNAs (miRNAs) are post-transcriptional gene regulators that are differentially expressed in several pathophysiological conditions including cancer. They impact the disease course by modulating an array of putative target gene(s). Interestingly, there is a strong correlation between the various miRNAs target(s) and the smoking-regulated genes in cancer. This review article provides an insight into the current status of smoking-induced miRNAs and their genetic/epigenetic regulation in smoking-associated cancers, with a major focus on lung cancer (LC). Furthermore, it discusses the role of miRNAs in smoking-mediated oncogenic events in cancer and explores the diagnostic/prognostic potential of miRNA-based biomarkers and their efficacy as therapeutic targets.

KW - Cancer

KW - Diagnostic

KW - Epigenetics

KW - MiRNA

KW - Signaling

KW - Smoking

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Smoking and microRNA dysregulation: A cancerous combination

Abstract

Keywords

ASJC Scopus subject areas

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