Sociodemographic Drivers of Donor and Recipient Gender Disparities in Living Kidney Donation in Australia

Siah Kim; Anita van Zwieten; Melanie Wyld; Maleeka Ladhani; Chandana Guha; Amanda Dominello; Kylie-Ann Mallitt; Anna Francis; Roslyn B Mannon; Germaine Wong

doi:10.1016/j.ekir.2023.05.016

Sociodemographic Drivers of Donor and Recipient Gender Disparities in Living Kidney Donation in Australia

Siah Kim, Anita van Zwieten, Melanie Wyld, Maleeka Ladhani, Chandana Guha, Amanda Dominello, Kylie-Ann Mallitt, Anna Francis, Roslyn B Mannon, Germaine Wong

Nephrology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

BACKGROUND: Females account for 60% of all living kidney donors worldwide. We defined the proportion of female to male donors for living donor kidney transplantation stratified by recipient gender, and explored the factors associated with female kidney donation.

METHODS: Data from the ANZDATA (Australian and New Zealand Dialysis and Transplantation) and ANZOD (Australian and New Zealand Organ Donor) registries (2002-2019) were used to identify the sociodemographic characteristics and their interactions associated with living donation from female donors. We derived the predicted probabilities from adjusted logistic models using marginal means.

RESULTS: Of 3523 living donor pairs, 2203 (63%) recipients were male, and 2012 (57%) donors were female. Male recipients were more likely to receive kidneys from female donors than male donors. Donor and recipient sex association was modified by donor-recipient relationship ( P < 0.01), with sensitivity analysis suggesting that spousal donor-recipient pairs drive this interaction. Older recipients residing in regional or remote areas were more likely to receive kidneys from female donors compared with those from major cities (aged ≥60 years: 0.67 [0.63-0.71] vs. aged <60 years: 0.57 [0.53-0.60]).

CONCLUSIONS: Factors associated with female donation include recipient sex, with spousal donors contributing to the interaction between recipient gender and donor-recipient relationship. Recipient age and location of residence have interactive effects on the likelihood of living donor transplantation from female donors.

Original language	English (US)
Pages (from-to)	1553-1561
Number of pages	9
Journal	Kidney International Reports
Volume	8
Issue number	8
DOIs	https://doi.org/10.1016/j.ekir.2023.05.016
State	Published - Aug 2023

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@article{db4863a23ef940b7b1d2b91920c8e529,

title = "Sociodemographic Drivers of Donor and Recipient Gender Disparities in Living Kidney Donation in Australia",

abstract = "BACKGROUND: Females account for 60% of all living kidney donors worldwide. We defined the proportion of female to male donors for living donor kidney transplantation stratified by recipient gender, and explored the factors associated with female kidney donation.METHODS: Data from the ANZDATA (Australian and New Zealand Dialysis and Transplantation) and ANZOD (Australian and New Zealand Organ Donor) registries (2002-2019) were used to identify the sociodemographic characteristics and their interactions associated with living donation from female donors. We derived the predicted probabilities from adjusted logistic models using marginal means.RESULTS: Of 3523 living donor pairs, 2203 (63%) recipients were male, and 2012 (57%) donors were female. Male recipients were more likely to receive kidneys from female donors than male donors. Donor and recipient sex association was modified by donor-recipient relationship ( P < 0.01), with sensitivity analysis suggesting that spousal donor-recipient pairs drive this interaction. Older recipients residing in regional or remote areas were more likely to receive kidneys from female donors compared with those from major cities (aged ≥60 years: 0.67 [0.63-0.71] vs. aged <60 years: 0.57 [0.53-0.60]). CONCLUSIONS: Factors associated with female donation include recipient sex, with spousal donors contributing to the interaction between recipient gender and donor-recipient relationship. Recipient age and location of residence have interactive effects on the likelihood of living donor transplantation from female donors.",

author = "Siah Kim and {van Zwieten}, Anita and Melanie Wyld and Maleeka Ladhani and Chandana Guha and Amanda Dominello and Kylie-Ann Mallitt and Anna Francis and Mannon, {Roslyn B} and Germaine Wong",

note = "{\textcopyright} 2023 International Society of Nephrology. Published by Elsevier Inc.",

year = "2023",

month = aug,

doi = "10.1016/j.ekir.2023.05.016",

language = "English (US)",

volume = "8",

pages = "1553--1561",

journal = "Kidney International Reports",

issn = "2468-0249",

publisher = "Elsevier Inc.",

number = "8",

}

TY - JOUR

T1 - Sociodemographic Drivers of Donor and Recipient Gender Disparities in Living Kidney Donation in Australia

AU - Kim, Siah

AU - van Zwieten, Anita

AU - Wyld, Melanie

AU - Ladhani, Maleeka

AU - Guha, Chandana

AU - Dominello, Amanda

AU - Mallitt, Kylie-Ann

AU - Francis, Anna

AU - Mannon, Roslyn B

AU - Wong, Germaine

PY - 2023/8

Y1 - 2023/8

N2 - BACKGROUND: Females account for 60% of all living kidney donors worldwide. We defined the proportion of female to male donors for living donor kidney transplantation stratified by recipient gender, and explored the factors associated with female kidney donation.METHODS: Data from the ANZDATA (Australian and New Zealand Dialysis and Transplantation) and ANZOD (Australian and New Zealand Organ Donor) registries (2002-2019) were used to identify the sociodemographic characteristics and their interactions associated with living donation from female donors. We derived the predicted probabilities from adjusted logistic models using marginal means.RESULTS: Of 3523 living donor pairs, 2203 (63%) recipients were male, and 2012 (57%) donors were female. Male recipients were more likely to receive kidneys from female donors than male donors. Donor and recipient sex association was modified by donor-recipient relationship ( P < 0.01), with sensitivity analysis suggesting that spousal donor-recipient pairs drive this interaction. Older recipients residing in regional or remote areas were more likely to receive kidneys from female donors compared with those from major cities (aged ≥60 years: 0.67 [0.63-0.71] vs. aged <60 years: 0.57 [0.53-0.60]). CONCLUSIONS: Factors associated with female donation include recipient sex, with spousal donors contributing to the interaction between recipient gender and donor-recipient relationship. Recipient age and location of residence have interactive effects on the likelihood of living donor transplantation from female donors.

AB - BACKGROUND: Females account for 60% of all living kidney donors worldwide. We defined the proportion of female to male donors for living donor kidney transplantation stratified by recipient gender, and explored the factors associated with female kidney donation.METHODS: Data from the ANZDATA (Australian and New Zealand Dialysis and Transplantation) and ANZOD (Australian and New Zealand Organ Donor) registries (2002-2019) were used to identify the sociodemographic characteristics and their interactions associated with living donation from female donors. We derived the predicted probabilities from adjusted logistic models using marginal means.RESULTS: Of 3523 living donor pairs, 2203 (63%) recipients were male, and 2012 (57%) donors were female. Male recipients were more likely to receive kidneys from female donors than male donors. Donor and recipient sex association was modified by donor-recipient relationship ( P < 0.01), with sensitivity analysis suggesting that spousal donor-recipient pairs drive this interaction. Older recipients residing in regional or remote areas were more likely to receive kidneys from female donors compared with those from major cities (aged ≥60 years: 0.67 [0.63-0.71] vs. aged <60 years: 0.57 [0.53-0.60]). CONCLUSIONS: Factors associated with female donation include recipient sex, with spousal donors contributing to the interaction between recipient gender and donor-recipient relationship. Recipient age and location of residence have interactive effects on the likelihood of living donor transplantation from female donors.

U2 - 10.1016/j.ekir.2023.05.016

DO - 10.1016/j.ekir.2023.05.016

M3 - Article

C2 - 37547516

SN - 2468-0249

VL - 8

SP - 1553

EP - 1561

JO - Kidney International Reports

JF - Kidney International Reports

IS - 8

ER -

Sociodemographic Drivers of Donor and Recipient Gender Disparities in Living Kidney Donation in Australia

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