TY - JOUR
T1 - Soft-Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications
AU - Elkhoury, Kamil
AU - Russell, Carina S.
AU - Sanchez-Gonzalez, Laura
AU - Mostafavi, Azadeh
AU - Williams, Tyrell J.
AU - Kahn, Cyril
AU - Peppas, Nicholas A.
AU - Arab-Tehrany, Elmira
AU - Tamayol, Ali
N1 - Funding Information:
K.E. and C.S.R. contributed equally to this work. A.T. acknowledges financial support from the National Institutes of Health (GM126831 and AR073822), the University of Nebraska-Lincoln, and the Nebraska Tobacco Settlement Biomedical Research Enhancement Funds. K.E. acknowledges financial support from the Ministry of Higher Education, Research and Innovation. N.A.P. acknowledges support in part by grant U54-143837-02 and R01-EB022025 from the National Institutes of Health (NIH), the Cockrell Family Regents Chair, and the Pratt Foundation.
Publisher Copyright:
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Tissue engineering has emerged as an important research area that provides numerous research tools for the fabrication of biologically functional constructs that can be used in drug discovery, disease modeling, and the treatment of diseased or injured organs. From a materials point of view, scaffolds have become an important part of tissue engineering activities and are usually used to form an environment supporting cellular growth, differentiation, and maturation. Among various materials used as scaffolds, hydrogels based on natural polymers are considered one of the most suitable groups of materials for creating tissue engineering scaffolds. Natural hydrogels, however, do not always provide the physicochemical and biological characteristics and properties required for optimal cell growth. This review discusses the properties and tissue engineering applications of widely used natural hydrogels. In addition, methods of modulation of their physicochemical and biological properties using soft nanoparticles as fillers or reinforcing agents are presented.
AB - Tissue engineering has emerged as an important research area that provides numerous research tools for the fabrication of biologically functional constructs that can be used in drug discovery, disease modeling, and the treatment of diseased or injured organs. From a materials point of view, scaffolds have become an important part of tissue engineering activities and are usually used to form an environment supporting cellular growth, differentiation, and maturation. Among various materials used as scaffolds, hydrogels based on natural polymers are considered one of the most suitable groups of materials for creating tissue engineering scaffolds. Natural hydrogels, however, do not always provide the physicochemical and biological characteristics and properties required for optimal cell growth. This review discusses the properties and tissue engineering applications of widely used natural hydrogels. In addition, methods of modulation of their physicochemical and biological properties using soft nanoparticles as fillers or reinforcing agents are presented.
KW - nanofunctionalization
KW - natural hydrogels
KW - soft nanoparticles
KW - tissue engineering
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U2 - 10.1002/adhm.201900506
DO - 10.1002/adhm.201900506
M3 - Review article
C2 - 31402589
AN - SCOPUS:85070703967
VL - 8
JO - Advanced healthcare materials
JF - Advanced healthcare materials
SN - 2192-2640
IS - 18
M1 - 1900506
ER -