Soft tissue angiofibroma: Report of 2 cases of a recently described tumor

Mark A. Edgar, Scott R. Lauer, Julia A. Bridge, Monica Rizzo

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Several soft tissue tumors are characterized by fibrous stroma with a conspicuous vascular component including cellular angiofibroma, nasopharyngeal angiofibroma, and solitary fibrous tumor. Recently, a distinctive fibroblastic tumor composed of bland spindle cells and a complex vascular network has been characterized morphologically and shown to harbor a recurrent t(5;8) translocation with AHRR-NCOA2 gene fusion. We report our recent experience with 2 examples of this benign tumor, the diagnosis for one of which was supported by fluorescence in situ hybridization for NCOA2 rearrangement. Identification of this tumor is important to prevent misdiagnosis as a low-grade sarcoma.

Original languageEnglish (US)
Pages (from-to)438-441
Number of pages4
JournalHuman Pathology
Issue number3
StatePublished - Mar 2013


  • Angiofibroma
  • Benign
  • Soft tissue mass
  • Translocation

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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