Soft tissue angiofibroma: Report of 2 cases of a recently described tumor

Mark A. Edgar; Scott R. Lauer; Julia A. Bridge; Monica Rizzo

doi:10.1016/j.humpath.2012.08.021

Soft tissue angiofibroma: Report of 2 cases of a recently described tumor

Mark A. Edgar, Scott R. Lauer, Julia A. Bridge, Monica Rizzo

Pathology & Microbiology

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Several soft tissue tumors are characterized by fibrous stroma with a conspicuous vascular component including cellular angiofibroma, nasopharyngeal angiofibroma, and solitary fibrous tumor. Recently, a distinctive fibroblastic tumor composed of bland spindle cells and a complex vascular network has been characterized morphologically and shown to harbor a recurrent t(5;8) translocation with AHRR-NCOA2 gene fusion. We report our recent experience with 2 examples of this benign tumor, the diagnosis for one of which was supported by fluorescence in situ hybridization for NCOA2 rearrangement. Identification of this tumor is important to prevent misdiagnosis as a low-grade sarcoma.

Original language	English (US)
Pages (from-to)	438-441
Number of pages	4
Journal	Human Pathology
Volume	44
Issue number	3
DOIs	https://doi.org/10.1016/j.humpath.2012.08.021
State	Published - Mar 2013

Keywords

Angiofibroma
Benign
Soft tissue mass
Translocation

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.humpath.2012.08.021

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title = "Soft tissue angiofibroma: Report of 2 cases of a recently described tumor",

abstract = "Several soft tissue tumors are characterized by fibrous stroma with a conspicuous vascular component including cellular angiofibroma, nasopharyngeal angiofibroma, and solitary fibrous tumor. Recently, a distinctive fibroblastic tumor composed of bland spindle cells and a complex vascular network has been characterized morphologically and shown to harbor a recurrent t(5;8) translocation with AHRR-NCOA2 gene fusion. We report our recent experience with 2 examples of this benign tumor, the diagnosis for one of which was supported by fluorescence in situ hybridization for NCOA2 rearrangement. Identification of this tumor is important to prevent misdiagnosis as a low-grade sarcoma.",

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AU - Edgar, Mark A.

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AU - Bridge, Julia A.

AU - Rizzo, Monica

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AB - Several soft tissue tumors are characterized by fibrous stroma with a conspicuous vascular component including cellular angiofibroma, nasopharyngeal angiofibroma, and solitary fibrous tumor. Recently, a distinctive fibroblastic tumor composed of bland spindle cells and a complex vascular network has been characterized morphologically and shown to harbor a recurrent t(5;8) translocation with AHRR-NCOA2 gene fusion. We report our recent experience with 2 examples of this benign tumor, the diagnosis for one of which was supported by fluorescence in situ hybridization for NCOA2 rearrangement. Identification of this tumor is important to prevent misdiagnosis as a low-grade sarcoma.

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KW - Benign

KW - Soft tissue mass

KW - Translocation

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Soft tissue angiofibroma: Report of 2 cases of a recently described tumor

Abstract

Keywords

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