Solid-phase synthesis of alkyl aryl ethers via the ullmann condensation

Xiao Yi Xiao, Rongshi Li, David Hurst, Hui Zhuang, Shuhao Shi, Anthony W. Czarnik, Albert J. Robichaud, Dean A. Wacker, David W. Robertson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Alkyl aryl ether formation is a frequently employed reaction in organic synthesis. Ullmann condensation is an alternative method to the widely used Mitsunobu reaction and is very useful in situations where application of the Mitsunobu reaction is limited. By application of this reaction to solid-phase synthesis of a series of alkyl aryl ethers, reaction conditions (catalyst, solvent, temperature, time, etc.) for a sterically hindered class of alcohols were investigated and optimized. A range of aryl halides was used to explore the scope of the reaction in solid phase.

Original languageEnglish (US)
Pages (from-to)536-539
Number of pages4
JournalJournal of Combinatorial Chemistry
Issue number5
StatePublished - Sep 2002
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)


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