Something Smells Fishy: How Lipid Mediators Impact the Maternal–Fetal Interface and Neonatal Development

Maranda Thompson; Arzu Ulu; Maheswari Mukherjee; Ana G. Yuil-Valdes; Melissa Thoene; Matthew Van Ormer; Rebecca Slotkowski; Teri Mauch; Ann Anderson-Berry; Corrine K. Hanson; Tara M. Nordgren; Sathish Kumar Natarajan

doi:10.3390/biomedicines11010171

Something Smells Fishy: How Lipid Mediators Impact the Maternal–Fetal Interface and Neonatal Development

Maranda Thompson, Arzu Ulu, Maheswari Mukherjee, Ana G. Yuil-Valdes, Melissa Thoene, Matthew Van Ormer, Rebecca Slotkowski, Teri Mauch, Ann Anderson-Berry, Corrine K. Hanson, Tara M. Nordgren, Sathish Kumar Natarajan

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Normal pregnancy relies on inflammation for implantation, placentation, and parturition, but uncontrolled inflammation can lead to poor maternal and infant outcomes. Maternal diet is one modifiable factor that can impact inflammation. Omega-3 and -6 fatty acids obtained through the diet are metabolized into bioactive compounds that effect inflammation. Recent evidence has shown that the downstream products of omega-3 and -6 fatty acids may influence physiology during pregnancy. In this review, the current knowledge relating to omega-3 and omega-6 metabolites during pregnancy will be summarized.

Original language	English (US)
Article number	171
Journal	Biomedicines
Volume	11
Issue number	1
DOIs	https://doi.org/10.3390/biomedicines11010171
State	Published - Jan 2023

Keywords

eicosanoids
fetal health
fish oils
inflammation
omega-3 fatty acid
omega-6 fatty acid
oxylipins
pregnancy
pro-resolving lipid mediator

ASJC Scopus subject areas

Medicine (miscellaneous)
General Biochemistry, Genetics and Molecular Biology

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10.3390/biomedicines11010171

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Thompson, M., Ulu, A., Mukherjee, M., Yuil-Valdes, A. G., Thoene, M., Van Ormer, M., Slotkowski, R., Mauch, T., Anderson-Berry, A., Hanson, C. K., Nordgren, T. M., & Natarajan, S. K. (2023). Something Smells Fishy: How Lipid Mediators Impact the Maternal–Fetal Interface and Neonatal Development. Biomedicines, 11(1), Article 171. https://doi.org/10.3390/biomedicines11010171

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abstract = "Normal pregnancy relies on inflammation for implantation, placentation, and parturition, but uncontrolled inflammation can lead to poor maternal and infant outcomes. Maternal diet is one modifiable factor that can impact inflammation. Omega-3 and -6 fatty acids obtained through the diet are metabolized into bioactive compounds that effect inflammation. Recent evidence has shown that the downstream products of omega-3 and -6 fatty acids may influence physiology during pregnancy. In this review, the current knowledge relating to omega-3 and omega-6 metabolites during pregnancy will be summarized.",

keywords = "eicosanoids, fetal health, fish oils, inflammation, omega-3 fatty acid, omega-6 fatty acid, oxylipins, pregnancy, pro-resolving lipid mediator",

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AU - Ulu, Arzu

AU - Mukherjee, Maheswari

AU - Yuil-Valdes, Ana G.

AU - Thoene, Melissa

AU - Van Ormer, Matthew

AU - Slotkowski, Rebecca

AU - Mauch, Teri

AU - Anderson-Berry, Ann

AU - Hanson, Corrine K.

AU - Nordgren, Tara M.

AU - Natarajan, Sathish Kumar

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AB - Normal pregnancy relies on inflammation for implantation, placentation, and parturition, but uncontrolled inflammation can lead to poor maternal and infant outcomes. Maternal diet is one modifiable factor that can impact inflammation. Omega-3 and -6 fatty acids obtained through the diet are metabolized into bioactive compounds that effect inflammation. Recent evidence has shown that the downstream products of omega-3 and -6 fatty acids may influence physiology during pregnancy. In this review, the current knowledge relating to omega-3 and omega-6 metabolites during pregnancy will be summarized.

KW - eicosanoids

KW - fetal health

KW - fish oils

KW - inflammation

KW - omega-3 fatty acid

KW - omega-6 fatty acid

KW - oxylipins

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Something Smells Fishy: How Lipid Mediators Impact the Maternal–Fetal Interface and Neonatal Development

Abstract

Keywords

ASJC Scopus subject areas

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