TY - JOUR
T1 - Somewhere over the sex differences rainbow of myocardial infarction remodeling
T2 - hormones, chromosomes, inflammasome, oh my
AU - DeLeon-Pennell, Kristine Y.
AU - Lindsey, Merry L.
N1 - Funding Information:
This paper was funded by the National Institutes of Health under award numbers HL075360, HL129823, and HL137319, U54DA016511, and from the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development under award numbers 5I01BX000505 and IK2BX003922. This work was also financially supported, in part, by the 2019 S&R Foundation Ryuji Ueno Award that was bestowed to Dr. DeLeon-Pennell by the American Physiological Society. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, the Veterans Administration, or the American Physiological Society.
PY - 2019/12/2
Y1 - 2019/12/2
N2 - Introduction: Cardiovascular disease is a major cause of death in both men and women. While women are protected until the onset of menopause, after menopause women have increased risk of adverse cardiovascular disease events. Animal models of myocardial infarction recapitulate many of the sex differences observed in humans, and proteomics evaluations offer mechanistic insights to explain sex differences. Areas covered: In this review, we will discuss how proteomics has helped us understand the hormonal, chromosomal, and immune mechanisms behind sex differences in response to ischemic injury and the development of heart failure. Expert opinion: There are a number of ways in which proteomics has and will continue to facilitate our understanding of sex differences in cardiac remodeling after myocardial infarction.
AB - Introduction: Cardiovascular disease is a major cause of death in both men and women. While women are protected until the onset of menopause, after menopause women have increased risk of adverse cardiovascular disease events. Animal models of myocardial infarction recapitulate many of the sex differences observed in humans, and proteomics evaluations offer mechanistic insights to explain sex differences. Areas covered: In this review, we will discuss how proteomics has helped us understand the hormonal, chromosomal, and immune mechanisms behind sex differences in response to ischemic injury and the development of heart failure. Expert opinion: There are a number of ways in which proteomics has and will continue to facilitate our understanding of sex differences in cardiac remodeling after myocardial infarction.
KW - inflammation
KW - myocardial infarction
KW - sex differences
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U2 - 10.1080/14789450.2019.1664293
DO - 10.1080/14789450.2019.1664293
M3 - Review article
C2 - 31483157
AN - SCOPUS:85073801577
VL - 16
SP - 933
EP - 940
JO - Expert Review of Proteomics
JF - Expert Review of Proteomics
SN - 1478-9450
IS - 11-12
ER -