Sonic hedgehog promotes desmoplasia in pancreatic cancer

Jennifer M. Bailey, Benjamin J. Swanson, Tomofumi Hamada, John P. Eggers, Pankaj K. Singh, Thomas Caffery, Michel M. Ouellette, Michael A. Hollingsworth

Research output: Contribution to journalArticlepeer-review

332 Scopus citations


Purpose: We investigated the contribution of Sonic hedgehog (SHH) to pancreatic cancer progression. Experimental Design: We expressed SHH in a transformed primary ductal-derived epithelial cell line from the human pancreas, transformed hTert-HPNE (T-HPNE), and evaluated the effects on tumor growth. We also directly inhibited the activity of SHH in vivo by administering a blocking antibody to mice challenged orthotopically with the Capan-2 pancreatic cancer cell line, which is known to express SHH and form moderately differentiated tumors in nude mice. Results: Our data provide evidence that expression of SHH influences tumor growth by contributing to the formation of desmoplasia in pancreatic cancer. We further show that SHH affects the differentiation and motility of human pancreatic stellate cells and fibroblasts. Conclusions: These data suggest that SHH contributes to the formation of desmoplasia in pancreatic cancer, an important component of the tumor microenvironment.

Original languageEnglish (US)
Pages (from-to)5995-6004
Number of pages10
JournalClinical Cancer Research
Issue number19
StatePublished - Oct 1 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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