Abstract
Grain sorghum is a rich source of phytochemicals. In this study, male hamsters were fed AIN-93M diets supplemented with a hexane-extractable lipid fraction from sorghum distillers dried grains with solubles (DDGS). Diets contained 0.0%, 0.5%, 1.0%, and 5.0% (w/w) DDGS lipid extract. After 4 wk, the 5.0% DDGS lipids group had significantly lower plasma non-HDL cholesterol and liver esterified cholesterol concentration. Faecal neutral sterol (i.e., cholesterol) excretion was significantly higher in the 5.0% DDGS lipids group compared to the other treatments (66% higher compared to controls). Bile acid excretion was not affected by DDGS lipid intake. Faecal cholesterol excretion was negatively correlated with liver cholesterol concentration (r = -0.97, P = 0.026), and liver cholesterol concentration was directly correlated with plasma total cholesterol concentration (r = 0.96, P = 0.041). Thus, lipid extract of sorghum DDGS exhibited cholesterol-lowering properties due, at least in part, to increased cholesterol excretion from the body and could provide health benefits when incorporated into human diets.
Original language | English (US) |
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Pages (from-to) | 381-386 |
Number of pages | 6 |
Journal | Journal of Functional Foods |
Volume | 1 |
Issue number | 4 |
DOIs | |
State | Published - Oct 2009 |
Keywords
- Cholesterol
- Hamsters
- Lipid extract
- Sorghum
- Sterols
ASJC Scopus subject areas
- Food Science
- Medicine (miscellaneous)
- Nutrition and Dietetics