@article{7f6dec56f384400fa7de437245cd16bc,
title = "Spatio-spectral relationships between pathological neural dynamics and cognitive impairment along the alzheimer{\textquoteright}s disease spectrum",
abstract = "Introduction: Numerous studies have described aberrant patterns of rhythmic neural activity in patients along the Alzheimer{\textquoteright}s disease (AD) spectrum, yet the relationships between these pathological features and cognitive decline are uncertain. Methods: We acquired magnetoencephalography (MEG) data from 38 amyloid-PET biomarker-confirmed patients on the AD spectrum and a comparison group of biomarker-negative cognitively normal (CN) healthy adults, alongside an extensive neuropsychological battery. Results: By modeling whole-brain rhythmic neural activity with an extensive neuropsy-chological profile in patients on the AD spectrum, we show that the spectral and spatial features of deviations from healthy adults in neural population-level activity inform their relevance to domain-specific neurocognitive declines. Discussion: Regional oscillatory activity represents a sensitive metric of neuronal pathology in patients on the AD spectrum. By considering not only the spatial, but also the spectral, definitions of cortical neuronal activity, we show that domain-specific cognitive declines can be better modeled in these individuals.",
keywords = "Neural oscillations, Neuropsychology, Resting-state magnetoencephalography",
author = "Wiesman, {Alex I.} and Murman, {Daniel L.} and May, {Pamela E.} and Mikki Schantell and Losh, {Rebecca A.} and Johnson, {Hallie J.} and Willet, {Madelyn P.} and Eastman, {Jacob A.} and Christopher-Hayes, {Nicholas J.} and Knott, {Nichole L.} and Houseman, {Lisa L.} and Wolfson, {Sara L.} and Losh, {Kathryn L.} and Johnson, {Craig M.} and Wilson, {Tony W.}",
note = "Funding Information: First and foremost, we would like to acknowledge the efforts of our research participants. Without their selflessness and kind demeanor, none of this work would have been possible. We would also like to thank the research and clinical staff who sustained patient recruitment and data collection for this study, Dr. Clifford Jack for helpful input regarding normalization of our PET data, as well as our funding sources for their support. Finally, we would like to extend our sincerest gratitude to the late Mr. Marvin Welstead, who selflessly dedicated so much of his time to raising funds for Alzheimer{\textquoteright}s disease research and education initiatives. This research was supported by grants R01-MH116782 (TWW), R01-MH118013 (TWW), R01-DA047828 (TWW), RF1-MH117032 (TWW), F31-AG055332 (AIW), and F32-NS119375 (AIW) from the National Institutes of Health, as well as by a grant from the Fremont Area Alzheimer{\textquoteright}s Fund (FAAF). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: First and foremost, we would like to acknowledge the efforts of our research participants. Without their selflessness and kind demeanor, none of this work would have been possible. We would also like to thank the research and clinical staff who sustained patient recruit-ment and data collection for this study, Dr. Clifford Jack for helpful input regarding normalization of our PET data, as well as our funding sources for their support. Finally, we would like to extend our sincerest gratitude to the late Mr. Marvin Welstead, who selflessly dedicated so much of his time to raising funds for Alzheimer?s disease research and education initiatives. This research was supported by grants R01-MH116782 (TWW), R01-MH118013 (TWW), R01-DA047828 (TWW), RF1-MH117032 (TWW), F31-AG055332 (AIW), and F32-NS119375 (AIW) from the National Institutes of Health, as well as by a grant from the Fremont Area Alzheimer?s Fund (FAAF). The funders had no role in study design, data collection and analysis, deci-sion to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2021 The Authors. Alzh.",
year = "2021",
doi = "10.1002/dad2.12200",
language = "English (US)",
volume = "13",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier BV",
number = "1",
}