Abstract
Fluorescent nanosensor probes have suffered from limited molecular recognition and a dearth of strategies for spatial-temporal operation in cell culture. In this work, we spatially imaged the dynamics of nitric oxide (NO) signaling, important in numerous pathologies and physiological functions, using intracellular near-infrared fluorescent single-walled carbon nanotubes. The observed spatial-temporal NO signaling gradients clarify and refine the existing paradigm of NO signaling based on averaged local concentrations. This work enables the study of transient intracellular phenomena associated with signaling and therapeutics.
Original language | English (US) |
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Pages (from-to) | 4887-4894 |
Number of pages | 8 |
Journal | Nano Letters |
Volume | 14 |
Issue number | 8 |
DOIs | |
State | Published - Aug 13 2014 |
Externally published | Yes |
Keywords
- Single-walled carbon nanotube
- nitric oxide
- photoluminescence
- sensor
ASJC Scopus subject areas
- Bioengineering
- General Chemistry
- General Materials Science
- Condensed Matter Physics
- Mechanical Engineering