Specific Uptake of the Auger Electron-emitting Thymidine Analogue 5-[123I/125I]Iodo-2'-deoxyuridine in Rat Brain Tumors: Diagnostic and Therapeutic Implications in Humans

Amin I. Kassis, Annick D. Van den Abbeele, Janina Baranowska-Kortylewicz, William C. DeSisto, Rebecca A. Aaronson, S. James Adelstein, Patrick Y.C. Wen, Lois A. Lampson, Peter Mc L. Black

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Glial neoplasms of the human central nervous system are malignancies that have defied treatment. Part of the problem lies in the limitations of current diagnostic techniques which are unable to identify small collections of neoplastic glia within normal parenchyma and in the difficulty of sterilizing these tumors because of limited selectivity of the cytotoxic agents available. The thymidine analogue 5-iodo-2'-deoxyuridine (IdUrd) radiolabeled with, 23I and 125I was injected directly into an intracerebral rat 9L gliosarcoma and found to be a sensitive and specific agent for the detection of this neoplasm in rats. External gamma camera imaging (,23I) visualized tumors as small as 0.5 mm in diameter. Autoradiography (125I) indicated that IdUrd was incorporated into the DNA of neoplastic glia only. Since 123I emits γ-photons suitable for scintigraphy, [123I]IdUrd holds promise for the diagnosis of brain tumors in humans as well. Furthermore, since 123I and, 25I are Auger electron emitters that have demonstrated antineoplastic effects, direct administration of [123I]IdUrd or [125I]IdUrd into tumors may also have potential for the treatment of central nervous system malignancies.

Original languageEnglish (US)
Pages (from-to)5199-5203
Number of pages5
JournalCancer Research
Volume50
Issue number16
StatePublished - Aug 15 1990

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Kassis, A. I., Van den Abbeele, A. D., Baranowska-Kortylewicz, J., DeSisto, W. C., Aaronson, R. A., Adelstein, S. J., Wen, P. Y. C., Lampson, L. A., & Black, P. M. L. (1990). Specific Uptake of the Auger Electron-emitting Thymidine Analogue 5-[123I/125I]Iodo-2'-deoxyuridine in Rat Brain Tumors: Diagnostic and Therapeutic Implications in Humans. Cancer Research, 50(16), 5199-5203.