TY - JOUR
T1 - Specific Uptake of the Auger Electron-emitting Thymidine Analogue 5-[123I/125I]Iodo-2'-deoxyuridine in Rat Brain Tumors
T2 - Diagnostic and Therapeutic Implications in Humans
AU - Kassis, Amin I.
AU - Van den Abbeele, Annick D.
AU - Baranowska-Kortylewicz, Janina
AU - DeSisto, William C.
AU - Aaronson, Rebecca A.
AU - Adelstein, S. James
AU - Wen, Patrick Y.C.
AU - Lampson, Lois A.
AU - Black, Peter Mc L.
PY - 1990/8/15
Y1 - 1990/8/15
N2 - Glial neoplasms of the human central nervous system are malignancies that have defied treatment. Part of the problem lies in the limitations of current diagnostic techniques which are unable to identify small collections of neoplastic glia within normal parenchyma and in the difficulty of sterilizing these tumors because of limited selectivity of the cytotoxic agents available. The thymidine analogue 5-iodo-2'-deoxyuridine (IdUrd) radiolabeled with, 23I and 125I was injected directly into an intracerebral rat 9L gliosarcoma and found to be a sensitive and specific agent for the detection of this neoplasm in rats. External gamma camera imaging (,23I) visualized tumors as small as 0.5 mm in diameter. Autoradiography (125I) indicated that IdUrd was incorporated into the DNA of neoplastic glia only. Since 123I emits γ-photons suitable for scintigraphy, [123I]IdUrd holds promise for the diagnosis of brain tumors in humans as well. Furthermore, since 123I and, 25I are Auger electron emitters that have demonstrated antineoplastic effects, direct administration of [123I]IdUrd or [125I]IdUrd into tumors may also have potential for the treatment of central nervous system malignancies.
AB - Glial neoplasms of the human central nervous system are malignancies that have defied treatment. Part of the problem lies in the limitations of current diagnostic techniques which are unable to identify small collections of neoplastic glia within normal parenchyma and in the difficulty of sterilizing these tumors because of limited selectivity of the cytotoxic agents available. The thymidine analogue 5-iodo-2'-deoxyuridine (IdUrd) radiolabeled with, 23I and 125I was injected directly into an intracerebral rat 9L gliosarcoma and found to be a sensitive and specific agent for the detection of this neoplasm in rats. External gamma camera imaging (,23I) visualized tumors as small as 0.5 mm in diameter. Autoradiography (125I) indicated that IdUrd was incorporated into the DNA of neoplastic glia only. Since 123I emits γ-photons suitable for scintigraphy, [123I]IdUrd holds promise for the diagnosis of brain tumors in humans as well. Furthermore, since 123I and, 25I are Auger electron emitters that have demonstrated antineoplastic effects, direct administration of [123I]IdUrd or [125I]IdUrd into tumors may also have potential for the treatment of central nervous system malignancies.
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M3 - Article
C2 - 2379179
AN - SCOPUS:0025002682
VL - 50
SP - 5199
EP - 5203
JO - Cancer Research
JF - Cancer Research
SN - 0008-5472
IS - 16
ER -