TY - JOUR
T1 - Spectral-domain optical coherence tomography epithelial and flap thickness mapping in femtosecond laser-assisted in situ keratomileusis
AU - Maia Rocha, Karolinne
AU - Krueger, Ronald R.
N1 - Funding Information:
Karolinne Maia Rocha graduated from ophthalmology residency, fellowship and PhD from Federal University of São Paulo. Subsequently she completed Cornea&Refractive Surgery postdoctoral fellowships at Cole Eye Institute and Emory University and a second residency in Ophthalmology at Cleveland Clinic. Dr Rocha will serve as an Assistant Professor at Medical University of South Carolina. She is a member of the executive subcommittee of the ISRS International Council and was recently honored with the AAO Achievement Award.
Funding Information:
Both authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Rocha indicates no financial conflict of interest; Dr Krueger is a consultant for Alcon. This study was supported in part by an unrestricted departmental grant from Research to Prevent Blindness , Inc, New York, New York and by a clinical study grant from Alcon , Fort Worth, Texas. Contributions of authors: involved in design of study (K.M.R., R.R.K.); conception and design (K.M.R., R.R.K.); analysis and interpretation of data (K.M.R., R.R.K.); preparation and writing of the article (K.M.R.); critical revision of the article (K.M.R., R.R.K.); final approval of the article (R.R.K.); data collection and literature search (K.M.R.).
PY - 2014/8
Y1 - 2014/8
N2 - Purpose To evaluate the change of epithelial and flap thickness after femtosecond laser-assisted in situ keratomileusis (LASIK) using spectral-domain optical coherence tomography (SD OCT) in correlation with the spherical equivalent refraction treated and clinical outcomes. Design Prospective, randomized, contralateral-eye study. Methods Forty myopic eyes underwent LASIK using an excimer laser with refraction ranging from -1.00 to -7.25 diopters (mean -3.25 ± 1.9). Flap creation was randomized between eyes, using the IntraLASE FS60 laser (IL) in 1 eye and WaveLight FS200 laser (FS) in the contralateral eye. SD OCT was used to evaluate the epithelial and flap thickness profiles and corneal power preoperatively and at 1 week and 1, 3, and 9 months postoperatively. Manifest and wavefront refractions were performed at each postoperative visit. Results Statistically significant epithelial thickening was observed in both IL and FS groups as early as 1 month postoperatively (P =.033 and P =.042), but this stabilized between 3 (P =.042 and P =.035) and 9 months (P =.043 and P =.041). Femtosecond-LASIK flaps were thicker in the IL group in comparison to the FS group at 3 and 9 months postoperatively (P =.003 and P =.005, respectively). There was a statistically significant correlation between the magnitude of preoperative myopic refraction and the central epithelial thickness at 1, 3, and 9 months (Pearson correlation coefficients 0.485, 0.587 and 0.576) (P =.0021, P =.0010, and P =.0011), respectively. SD OCT corneal power maps showed steepening at 3 and 9 months along with mild myopic shift. Conclusion Progressive epithelial and flap thickening with increased corneal power were observed after femtosecond laser-assisted in situ keratomileusis for myopia with consequent stabilization between 3 to 9 months postoperatively. The magnitude of epithelial and flap thickness remodeling correlated to the preoperative myopic refractive error.
AB - Purpose To evaluate the change of epithelial and flap thickness after femtosecond laser-assisted in situ keratomileusis (LASIK) using spectral-domain optical coherence tomography (SD OCT) in correlation with the spherical equivalent refraction treated and clinical outcomes. Design Prospective, randomized, contralateral-eye study. Methods Forty myopic eyes underwent LASIK using an excimer laser with refraction ranging from -1.00 to -7.25 diopters (mean -3.25 ± 1.9). Flap creation was randomized between eyes, using the IntraLASE FS60 laser (IL) in 1 eye and WaveLight FS200 laser (FS) in the contralateral eye. SD OCT was used to evaluate the epithelial and flap thickness profiles and corneal power preoperatively and at 1 week and 1, 3, and 9 months postoperatively. Manifest and wavefront refractions were performed at each postoperative visit. Results Statistically significant epithelial thickening was observed in both IL and FS groups as early as 1 month postoperatively (P =.033 and P =.042), but this stabilized between 3 (P =.042 and P =.035) and 9 months (P =.043 and P =.041). Femtosecond-LASIK flaps were thicker in the IL group in comparison to the FS group at 3 and 9 months postoperatively (P =.003 and P =.005, respectively). There was a statistically significant correlation between the magnitude of preoperative myopic refraction and the central epithelial thickness at 1, 3, and 9 months (Pearson correlation coefficients 0.485, 0.587 and 0.576) (P =.0021, P =.0010, and P =.0011), respectively. SD OCT corneal power maps showed steepening at 3 and 9 months along with mild myopic shift. Conclusion Progressive epithelial and flap thickening with increased corneal power were observed after femtosecond laser-assisted in situ keratomileusis for myopia with consequent stabilization between 3 to 9 months postoperatively. The magnitude of epithelial and flap thickness remodeling correlated to the preoperative myopic refractive error.
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U2 - 10.1016/j.ajo.2014.04.012
DO - 10.1016/j.ajo.2014.04.012
M3 - Article
C2 - 24792107
AN - SCOPUS:84905118667
SN - 0002-9394
VL - 158
SP - 293-301.e1
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 2
ER -