Spinal epidural hematoma following coronary thrombolysis with tissue plasminogen activator. Report of two cases

P. D. Sawin, V. C. Traynelis, K. A. Follett

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

Two cases of spinal epidural hematoma following intravenous administration of recombinant tissue-type plasminogen activator are presented. Both patients received thrombolytic therapy for acute myocardial infarction; back pain and progressive neurological dysfunction ensued, secondary to spinal cord compression caused by epidural hematoma. Both individuals underwent emergency surgery for decompression and hematoma evacuation, resulting in improvement in neurological function. The current status of thrombolytic therapy is reviewed, with emphasis on complications of therapy that require neurosurgical intervention.

Original languageEnglish (US)
Pages (from-to)350-353
Number of pages4
JournalJournal of neurosurgery
Volume83
Issue number2
DOIs
StatePublished - 1995

Keywords

  • epidural hematoma
  • myocardial infarction
  • spine
  • tissue plasminogen activator

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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