Spline-based semiparametric projected generalized estimating equation method for panel count data

Lei Hua, Ying Zhang

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


We propose to analyze panel count data using a spline-based semiparametric projected generalized estimating equation (GEE) method with the proportional mean model E((t)Z) = Λ0(t) eβ0TZ. The natural logarithm of the baseline mean function, logΛ0(t), is approximated by a monotone cubic B-spline function. The estimates of regression parameters and spline coefficients are obtained by projecting the GEE estimates into the feasible domain using a weighted isotonic regression (IR). The proposed method avoids assuming any parametric structure of the baseline mean function or any stochastic model for the underlying counting process. Selection of the working covariance matrix that accounts for overdispersion improves the estimation efficiency and leads to less biased variance estimations. Simulation studies are conducted using different working covariance matrices in the GEE to investigate finite sample performance of the proposed method, to compare the estimation efficiency, and to explore the performance of different variance estimates in presence of overdispersion. Finally, the proposed method is applied to a real data set from a bladder tumor clinical trial. The Author 2011. Published by Oxford University Press. All rights reserved.

Original languageEnglish (US)
Pages (from-to)440-454
Number of pages15
Issue number3
StatePublished - Jul 2012
Externally publishedYes


  • Counting process
  • Generalized estimating equation
  • Monotone B-splines
  • Overdispersion
  • Semiparametric model

ASJC Scopus subject areas

  • Statistics and Probability
  • Statistics, Probability and Uncertainty


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