Stably DNA-bound chromosomal proteins

Roumen Tsanev; Zoya Avramova

doi:10.1007/BF00417876

Stably DNA-bound chromosomal proteins

Roumen Tsanev, Zoya Avramova

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

DNA accomplishes its biological function in a complex with nuclear proteins. A minor protein fraction has been found in chromatin which could not be dissociated from DNA by reagents abolishing non-covalent type of interactions. The controversy surrounding the nature of the protein moiety and the nature of the bond linking the two components on the one hand, and the fact pointing to its evolutionary conservatism and metabolic stability on the other, make it necessary to critically evaluate the data in view of the possible biological function for such proteins.

Original language	English (US)
Pages (from-to)	293-301
Number of pages	9
Journal	Chromosoma
Volume	103
Issue number	5
DOIs	https://doi.org/10.1007/BF00417876
State	Published - Sep 1994
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1007/BF00417876

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abstract = "DNA accomplishes its biological function in a complex with nuclear proteins. A minor protein fraction has been found in chromatin which could not be dissociated from DNA by reagents abolishing non-covalent type of interactions. The controversy surrounding the nature of the protein moiety and the nature of the bond linking the two components on the one hand, and the fact pointing to its evolutionary conservatism and metabolic stability on the other, make it necessary to critically evaluate the data in view of the possible biological function for such proteins.",

author = "Roumen Tsanev and Zoya Avramova",

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AB - DNA accomplishes its biological function in a complex with nuclear proteins. A minor protein fraction has been found in chromatin which could not be dissociated from DNA by reagents abolishing non-covalent type of interactions. The controversy surrounding the nature of the protein moiety and the nature of the bond linking the two components on the one hand, and the fact pointing to its evolutionary conservatism and metabolic stability on the other, make it necessary to critically evaluate the data in view of the possible biological function for such proteins.

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Stably DNA-bound chromosomal proteins

Abstract

ASJC Scopus subject areas

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