Stably DNA-bound chromosomal proteins

Roumen Tsanev, Zoya Avramova

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


DNA accomplishes its biological function in a complex with nuclear proteins. A minor protein fraction has been found in chromatin which could not be dissociated from DNA by reagents abolishing non-covalent type of interactions. The controversy surrounding the nature of the protein moiety and the nature of the bond linking the two components on the one hand, and the fact pointing to its evolutionary conservatism and metabolic stability on the other, make it necessary to critically evaluate the data in view of the possible biological function for such proteins.

Original languageEnglish (US)
Pages (from-to)293-301
Number of pages9
Issue number5
StatePublished - Sep 1994
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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