@article{72690324886d4e9eaf7c3666abbabfb6,
title = "Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA",
abstract = "Tumor necrosis factor (TNF) α-induced nuclear translocation of the NF-κB subunit RELA has been implicated in several pathological conditions. Here we report the discovery of a spirocyclic dimer (SpiD7) that covalently modifies RELA to inhibit TNFα-induced nuclear translocation. This is a previously unexplored strategy to inhibit TNFα-induced NF-κB activation.",
author = "Smit Kour and Sandeep Rana and Smitha Kizhake and Dragana Lagund{\v z}in and David Klinkebiel and Mallareddy, {Jayapal Reddy} and Tom Huxford and Woods, {Nicholas T.} and Amarnath Natarajan",
note = "Funding Information: This work was supported in part by NIH grants CA197999, CA127297 and CA036727. S. Ko was supported by a predoctoral UNMC fellowship. Research resources at UNMC are supported in part by the Nebraska Research Initiative. Biochemistry research at SDSU is supported in part by the California Metabolic Research Foundation. We would like to thank the Natar-ajan lab members for helpful discussions. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",
year = "2022",
month = jan,
doi = "10.1039/d1cb00183c",
language = "English (US)",
volume = "3",
pages = "32--36",
journal = "RSC Chemical Biology",
issn = "2633-0679",
publisher = "Royal Society of Chemistry",
number = "1",
}