Abstract
Tumor necrosis factor (TNF) α-induced nuclear translocation of the NF-κB subunit RELA has been implicated in several pathological conditions. Here we report the discovery of a spirocyclic dimer (SpiD7) that covalently modifies RELA to inhibit TNFα-induced nuclear translocation. This is a previously unexplored strategy to inhibit TNFα-induced NF-κB activation.
Original language | English (US) |
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Pages (from-to) | 32-36 |
Number of pages | 5 |
Journal | RSC Chemical Biology |
Volume | 3 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2022 |
ASJC Scopus subject areas
- Chemistry (miscellaneous)
- Biochemistry
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology (miscellaneous)