State-of-the-Art Review of 3D Bioprinting for Cardiovascular Tissue Engineering

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104 Scopus citations

Abstract

3D bioprinting is a group of rapidly growing techniques that allows building engineered tissue constructs with complex and hierarchical structures, mechanical and biological heterogeneity. It enables implementation of various bioinks through different printing mechanisms and precise deposition of cell and/or biomolecule laden biomaterials in predefined locations. This review briefly summarizes applicable bioink materials and various bioprinting techniques, and presents the recent advances in bioprinting of cardiovascular tissues, with focusing on vascularized constructs, myocardium and heart valve conduits. Current challenges and further perspectives are also discussed to help guide the bioink and bioprinter development, improve bioprinting strategies and direct future organ bioprinting and translational applications.

Original languageEnglish (US)
Pages (from-to)195-209
Number of pages15
JournalAnnals of biomedical engineering
Volume45
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • Bioink
  • Heart valve
  • Hydrogel
  • Organ Bioprinting
  • Vascularization

ASJC Scopus subject areas

  • Biomedical Engineering

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