State-of-the-art: Rheumatoid arthritis

Iain B. McInnes, James R. O'Dell

Research output: Contribution to journalReview article

204 Scopus citations

Abstract

The understanding of the pathogenesis and optimal therapeutics for rheumatoid arthritis (RA) has advanced remarkably over the last decade. This review highlights these key advances, particularly the outcomes of genome-wide scans which have provided an increasingly robust appraisal of the complex genetics that underpin RA. Such observations are placed in pathogenetic context, particularly concerning the breach of tolerance that presages synovitis and the mechanisms that subserve chronicity. The key therapeutic strategies and treatment agents, both conventional and biological, now available to effectively manage the disease are described. Throughout the review, emphasis is placed on unanswered questions and challenges in this exciting field.

Original languageEnglish (US)
Pages (from-to)1898-1906
Number of pages9
JournalAnnals of the rheumatic diseases
Volume69
Issue number11
DOIs
StatePublished - Nov 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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