Stathmin expression in metastatic colorectal cancer

Premila D. Leiphrakpam, Audrey J. Lazenby, Lynette M. Smith, Michael G. Brattain, Chandrakanth Are

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To evaluate the relationship between stathmin expression and clinical outcome in colorectal cancer (CRC). Background: Stathmin is a phosphoprotein involved in the regulation of microtubule dynamics and integration of intracellular signaling pathways. Stathmin has been implicated in the tumorigenesis of several cancers and is a potential therapeutic target. Methods: Stathmin expression was evaluated in 25 metastatic CRC (mCRC) patients by immunohistochemistry (IHC). Ki67 IHC and TUNEL assay were also evaluated in mCRC for cell proliferation and apoptosis. Results: High expression of stathmin was correlated with CRC metastasis (p =.0084), and significantly worse overall survival (OS) in CRC patients (p =.036). There was a significant increase in cell proliferation and a decrease in apoptosis in liver metastasis compared with CRC primary tumors as determined by Ki67 IHC and TUNEL assay (p <.0001). We also observed a significant positive correlation between stathmin level and cell proliferation in both CRC primary tumor and liver metastasis (p =.0429 to 0.0451; r =.4236 to.4288). Conclusion: Stathmin expression correlated with worse patient prognosis in mCRC patients and positively correlated with increased cell proliferation. Together, our findings indicate stathmin as a novel potential marker for increased risk of CRC-specific mortality and identify stathmin as an attractive therapeutic target for the treatment of mCRC.

Original languageEnglish (US)
Pages (from-to)1764-1772
Number of pages9
JournalJournal of Surgical Oncology
Volume123
Issue number8
DOIs
StateAccepted/In press - 2021
Externally publishedYes

Keywords

  • apoptosis
  • cell proliferation
  • immunohistochemistry
  • overall survival

ASJC Scopus subject areas

  • Surgery
  • Oncology

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