Status of retinoids and carotenoids and associations with clinical outcomes in maternal-infant pairs in Nigeria

Corrine Hanson, Elizabeth Lyden, Ann Anderson-Berry, Nicholas Kocmich, Amy Rezac, Shirley Delair, Jeremy Furtado, Matthew Van Ormer, N. I. Izevbigie, E. D. Olateju, G. A. Adaba, E. A. Anigilaje, Tahiru Tahiru, Stephen Obaro

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Vitamin A is an essential nutrient in pregnancy, and other carotenoids have been independently associated with maternal-infant outcomes. The objective of this study was to quantify the status of vitamin A and carotenoids in Nigerian maternal-infant pairs at delivery, compare these to a cohort from a developed nation, and determine the impact on clinical outcomes. Maternal and cord blood samples were collected in 99 Nigerian mother-infant pairs. Concentrations of lutein + zeaxanthin, β-cryptoxanthin, lycopene, α- and β-carotenes, and retinol were measured using HPLC. Descriptive statistics were calculated and Spearman coefficients were used to assess correlations between maternal and cord measurements; Mann-Whitney tests were used to compare median plasma values between dichotomous variables. Linear regression models were used to adjust for relevant confounders. A p < 0.05 was considered statistically significant. Thirty-five percent of mothers had plasma retinol concentrations ≤0.70 µmol/L; 82% of infants had plasma retinol concentrations ≤0.70 µmol/L at delivery. Maternal and infant concentrations of vitamin A compounds were highly correlated and were associated with newborn growth and Apgar scores. Despite plasma concentrations of pro-vitamin A carotenoids higher than those reported in other populations, pregnant Nigerian women have a high prevalence of vitamin A deficiency. As vitamin A related compounds are modifiable by diet, future research determining the clinical impact of these compounds is warranted.

Original languageEnglish (US)
Article number1286
JournalNutrients
Volume10
Issue number9
DOIs
StatePublished - Sep 12 2018

Keywords

  • Carotenoids
  • Lutein
  • Maternal-child
  • Pregnancy
  • Vitamin A
  • β-carotene

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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    Hanson, C., Lyden, E., Anderson-Berry, A., Kocmich, N., Rezac, A., Delair, S., Furtado, J., Van Ormer, M., Izevbigie, N. I., Olateju, E. D., Adaba, G. A., Anigilaje, E. A., Tahiru, T., & Obaro, S. (2018). Status of retinoids and carotenoids and associations with clinical outcomes in maternal-infant pairs in Nigeria. Nutrients, 10(9), [1286]. https://doi.org/10.3390/nu10091286