@article{9d7a3964420e475e9a0420177303c95b,
title = "Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases",
abstract = "Astroglia are a major cellular constituent of the central nervous system (CNS) and play crucial roles in brain development, function, and integrity. Increasing evidence demonstrates that astroglia dysfunction occurs in a variety of neurological disorders ranging from CNS injuries to genetic diseases and chronic degenerative conditions. These new insights herald the concept that transplantation of astroglia could be of therapeutic value in treating the injured or diseased CNS. Recent technological advances in the generation of human astroglia from stem and progenitor cells have been prominent. We propose that a better understanding of the suitability of astroglial cells in transplantation as well as of their therapeutic effects in animal models may lead to the establishment of astroglia-based therapies to treat neurological diseases.",
author = "Chen Chen and Albert Chan and Han Wen and Chung, {Seung Hyuk} and Wenbin Deng and Peng Jiang",
note = "Funding Information: A search of clinicaltrials.gov revealed only one clinical trial investigating the use of human astroglia-based transplantation therapy at the time of this writing. The proposed study is a Phase 1/2 trial investigating the safety of hGRPs in patients with ALS ( NCT02478450 ). Grants from the California Institute for Regenerative Medicine (DR1-01471) and the U.S. Army Medical Research and Materiel Command (W81XWH-10-1-0520) proposed to study the preclinical efficacy of transplantation of human astroglia differentiated from human fetal-derived or iPSC-derived GRPs in ALS. The therapeutic potential of astroglial transplantation for the treatment of neurodegenerative diseases in animal models is evident. The combined current lack of effective therapy and the relative paucity of translational studies and clinical trials at this time highlight the need for further experimental studies to validate the clinical use of human astroglial transplantation to mitigate the devastating morbidity and mortality resulting from neurological diseases and CNS injuries. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",
year = "2015",
month = nov,
doi = "10.1016/j.molmed.2015.09.003",
language = "English (US)",
volume = "21",
pages = "715--729",
journal = "Trends in Molecular Medicine",
issn = "1471-4914",
publisher = "Elsevier Ltd",
number = "11",
}