Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases

Chen Chen, Albert Chan, Han Wen, Seung Hyuk Chung, Wenbin Deng, Peng Jiang

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Astroglia are a major cellular constituent of the central nervous system (CNS) and play crucial roles in brain development, function, and integrity. Increasing evidence demonstrates that astroglia dysfunction occurs in a variety of neurological disorders ranging from CNS injuries to genetic diseases and chronic degenerative conditions. These new insights herald the concept that transplantation of astroglia could be of therapeutic value in treating the injured or diseased CNS. Recent technological advances in the generation of human astroglia from stem and progenitor cells have been prominent. We propose that a better understanding of the suitability of astroglial cells in transplantation as well as of their therapeutic effects in animal models may lead to the establishment of astroglia-based therapies to treat neurological diseases.

Original languageEnglish (US)
Pages (from-to)715-729
Number of pages15
JournalTrends in Molecular Medicine
Volume21
Issue number11
DOIs
StatePublished - Nov 2015

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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