TY - JOUR
T1 - Stem cell therapy for retinal degeneration
T2 - Retinal neurons from heterologous sources
AU - Das, Ani M.
AU - Zhao, Xing
AU - Ahmad, Iqbal
N1 - Funding Information:
Address correspondence to Dr. Iqbal Ahmad, Dept. of Ophthalmology and Visual Sciences, 4044 Durham Research Center, 5840 Nebraska Medical Center, Omaha, NE 68198-5840, USA. E-mail: [email protected] This work was supported by NEI and Research to Prevent Blindness.
PY - 2005/1
Y1 - 2005/1
N2 - Over the past few years a great deal of interest has been generated in using stem cells/progenitors to treat degenerative diseases that afflict different tissues, including retina. This interest is due to the defining properties of stem cells/progenitors, the ability of these cells to self-renew and generate all the basic cell types of the particular tissue to which they belong. In addition, the recent reports of plasticity of the adult tissue-specific stem cells/progenitors and directed differentiation of the embryonic cells (ES) has fueled the hope for cell and gene therapy using stem cells from heterologous sources. Will this approach work for treating retinal degeneration? Here, we review the current state of knowledge about obtaining retinal cells from heterologous sources, including ES cells.
AB - Over the past few years a great deal of interest has been generated in using stem cells/progenitors to treat degenerative diseases that afflict different tissues, including retina. This interest is due to the defining properties of stem cells/progenitors, the ability of these cells to self-renew and generate all the basic cell types of the particular tissue to which they belong. In addition, the recent reports of plasticity of the adult tissue-specific stem cells/progenitors and directed differentiation of the embryonic cells (ES) has fueled the hope for cell and gene therapy using stem cells from heterologous sources. Will this approach work for treating retinal degeneration? Here, we review the current state of knowledge about obtaining retinal cells from heterologous sources, including ES cells.
KW - Degeneration
KW - Progenitors
KW - Retina
KW - Stem cells
KW - Transdifferentiation
UR - http://www.scopus.com/inward/record.url?scp=17444402061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=17444402061&partnerID=8YFLogxK
U2 - 10.1080/08820530590921882
DO - 10.1080/08820530590921882
M3 - Review article
C2 - 15804838
AN - SCOPUS:17444402061
SN - 0882-0538
VL - 20
SP - 3
EP - 10
JO - Seminars in Ophthalmology
JF - Seminars in Ophthalmology
IS - 1
ER -