Stem Cells, Induced Pluripotent Stem Cells, and Their Differentiation to Specified Lineage Fates

George T.J. Huang, Xiao Ying Zou, Xing Yan, Kyle J. Hewitt, Yulia Shamis, Jonathan A. Garlick

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Stem cell biology focuses on an understanding of a full spectrum of cell behaviors from the stem cell state to the fully differentiated condition. It examines the dynamics of cell physiology as to how stem cells maintain their stemness and give rise to specialized cells. Furthermore, this field has become a fundamental underpinning for the establishment of regenerative medicine and cell-based therapies. The differentiation approach to induced pluripotent stem cells (iPSCs) provides a more controlled environment to direct cells to specific lineage fates and to monitor cell differentiation toward a desired germ layer or cell type. While pluripotent cell types have been shown to be remarkably resistant to chromosomal abnormalities, both embryonic stem cells (ESCs) and iPSCs have been shown to acquire aberrant karyotypes following prolonged culture.

Original languageEnglish (US)
Title of host publicationStem Cells in Craniofacial Development and Regeneration
PublisherJohn Wiley and Sons
Number of pages19
ISBN (Print)9781118279236
StatePublished - Mar 26 2013
Externally publishedYes


  • Differentiation approach
  • Embryonic stem cells (ESCs)
  • Induced pluripotent stem cells (iPSCs)
  • Lineage fates
  • Stem cell biology

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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