Stem cell biology focuses on an understanding of a full spectrum of cell behaviors from the stem cell state to the fully differentiated condition. It examines the dynamics of cell physiology as to how stem cells maintain their stemness and give rise to specialized cells. Furthermore, this field has become a fundamental underpinning for the establishment of regenerative medicine and cell-based therapies. The differentiation approach to induced pluripotent stem cells (iPSCs) provides a more controlled environment to direct cells to specific lineage fates and to monitor cell differentiation toward a desired germ layer or cell type. While pluripotent cell types have been shown to be remarkably resistant to chromosomal abnormalities, both embryonic stem cells (ESCs) and iPSCs have been shown to acquire aberrant karyotypes following prolonged culture.
- Differentiation approach
- Embryonic stem cells (ESCs)
- Induced pluripotent stem cells (iPSCs)
- Lineage fates
- Stem cell biology
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)