Abstract
A stereoselective method for preparing 3-hydroxy-4-alkyl-γ-lactones is reported. iodolactonization of 3-hydroxy-4-alkenoic acids produces predominantly the thermodynamically less stable 3,4-cis products, which undergo methanolysis to threo-epoxyalcohols.
Original language | English (US) |
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Pages (from-to) | 4611-4614 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 22 |
Issue number | 46 |
DOIs | |
State | Published - 1981 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry