Stereoselective Synthesis of Homoneryl and Homogeranyl Triazole Bisphosphonates

Robert A. Matthiesen, Veronica S. Wills, Joseph I. Metzger, Sarah A. Holstein, David F. Wiemer

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Isoprenoid-substituted bisphosphonates are known to serve as inhibitors of the enzyme geranylgeranyl diphosphate synthase, and their activity can be highly sensitive to olefin stereochemistry. A mixture of homogeranyl and homoneryl triazole bisphosphonates has previously demonstrated potent activity, and thus stereocontrolled syntheses of the individual isomers have been developed.

Original languageEnglish (US)
Pages (from-to)9438-9442
Number of pages5
JournalJournal of Organic Chemistry
Volume81
Issue number19
DOIs
StatePublished - Oct 7 2016

ASJC Scopus subject areas

  • Organic Chemistry

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