@article{5d0cb5b12c2744bba82a43466a7b1f5f,
title = "Stereoselective Synthesis of Homoneryl and Homogeranyl Triazole Bisphosphonates",
abstract = "Isoprenoid-substituted bisphosphonates are known to serve as inhibitors of the enzyme geranylgeranyl diphosphate synthase, and their activity can be highly sensitive to olefin stereochemistry. A mixture of homogeranyl and homoneryl triazole bisphosphonates has previously demonstrated potent activity, and thus stereocontrolled syntheses of the individual isomers have been developed.",
author = "Matthiesen, {Robert A.} and Wills, {Veronica S.} and Metzger, {Joseph I.} and Holstein, {Sarah A.} and Wiemer, {David F.}",
note = "Funding Information: We thank the UI Graduate College for a Deans Graduate Fellowship and an AGEP Fellowship (to V.S.W.) and the Center for Biocatalysis and Bioprocessing for a fellowship (to V.S.W.) through the predoctoral Training Program in Biotechnology (T32 GM008365). Financial support from the National Institutes of Health (R01CA-172070) and the Roy J. Carver Charitable Trust (#01-224) through its research Program of Excellence (to D.F.W.) is greatly appreciated. Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",
year = "2016",
month = oct,
day = "7",
doi = "10.1021/acs.joc.6b01693",
language = "English (US)",
volume = "81",
pages = "9438--9442",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "19",
}