Stereostructure-activity relationships of the GABA-containing cis-decahydroquinoline-5-carboxylic acids; Intracerebroventricular studies in mice

Y. K. Fung; C. Bero; D. Dircks; K. Tomita; R. J. Patch; D. T. Witiak

Stereostructure-activity relationships of the GABA-containing cis-decahydroquinoline-5-carboxylic acids; Intracerebroventricular studies in mice

Y. K. Fung, C. Bero, D. Dircks, K. Tomita, R. J. Patch, D. T. Witiak

Oral Biology

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Abstract

Two cis-decahydroquinoline-5-carboxylic acids, cis-1 and 2 were investigated for their pharmacological activities in vivo. Intracerebroventricular administration of either agent elicited convulsant activity in mice. This convulsant effect can be antagonized by pretreating the mice with n-dipropylacetate (valproate). Our results suggest that cis-1 may act indirectly as a partial γ-aminobutyric acid (GABA) agonist in vivo. On the other hand, both cis-1 and 2, at higher concentrations, exhibit properties of a GABA-antagonist, but this effect seems not to be due to GABA receptor binding.

Original language	English (US)
Pages (from-to)	367-380
Number of pages	14
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	39
Issue number	3
State	Published - 1983

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
Pharmacology
Pharmacology, Toxicology and Pharmaceutics(all)

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abstract = "Two cis-decahydroquinoline-5-carboxylic acids, cis-1 and 2 were investigated for their pharmacological activities in vivo. Intracerebroventricular administration of either agent elicited convulsant activity in mice. This convulsant effect can be antagonized by pretreating the mice with n-dipropylacetate (valproate). Our results suggest that cis-1 may act indirectly as a partial γ-aminobutyric acid (GABA) agonist in vivo. On the other hand, both cis-1 and 2, at higher concentrations, exhibit properties of a GABA-antagonist, but this effect seems not to be due to GABA receptor binding.",

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T1 - Stereostructure-activity relationships of the GABA-containing cis-decahydroquinoline-5-carboxylic acids; Intracerebroventricular studies in mice

AU - Fung, Y. K.

AU - Bero, C.

AU - Dircks, D.

AU - Tomita, K.

AU - Patch, R. J.

AU - Witiak, D. T.

PY - 1983

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AB - Two cis-decahydroquinoline-5-carboxylic acids, cis-1 and 2 were investigated for their pharmacological activities in vivo. Intracerebroventricular administration of either agent elicited convulsant activity in mice. This convulsant effect can be antagonized by pretreating the mice with n-dipropylacetate (valproate). Our results suggest that cis-1 may act indirectly as a partial γ-aminobutyric acid (GABA) agonist in vivo. On the other hand, both cis-1 and 2, at higher concentrations, exhibit properties of a GABA-antagonist, but this effect seems not to be due to GABA receptor binding.

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Stereostructure-activity relationships of the GABA-containing cis-decahydroquinoline-5-carboxylic acids; Intracerebroventricular studies in mice

Abstract

ASJC Scopus subject areas

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