Two cis-decahydroquinoline-5-carboxylic acids, cis-1 and 2 were investigated for their pharmacological activities in vivo. Intracerebroventricular administration of either agent elicited convulsant activity in mice. This convulsant effect can be antagonized by pretreating the mice with n-dipropylacetate (valproate). Our results suggest that cis-1 may act indirectly as a partial γ-aminobutyric acid (GABA) agonist in vivo. On the other hand, both cis-1 and 2, at higher concentrations, exhibit properties of a GABA-antagonist, but this effect seems not to be due to GABA receptor binding.
|Original language||English (US)|
|Number of pages||14|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|State||Published - 1983|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)