Sticky, Adaptable, and Many-sided: SAM protein versatility in normal and pathological hematopoietic states

Suhita Ray, Kyle Hewitt

Research output: Contribution to journalReview articlepeer-review

Abstract

With decades of research seeking to generalize sterile alpha motif (SAM) biology, many outstanding questions remain regarding this multi-tool protein module. Recent data from structural and molecular/cell biology has begun to reveal new SAM modes of action in cell signaling cascades and biomolecular condensation. SAM-dependent mechanisms underlie blood-related (hematologic) diseases, including myelodysplastic syndromes and leukemias, prompting our focus on hematopoiesis for this review. With the increasing coverage of SAM-dependent interactomes, a hypothesis emerges that SAM interaction partners and binding affinities work to fine tune cell signaling cascades in developmental and disease contexts, including hematopoiesis and hematologic disease. This review discusses what is known and remains unknown about the standard mechanisms and neoplastic properties of SAM domains and what the future might hold for developing SAM-targeted therapies.

Original languageEnglish (US)
Article number2300022
JournalBioEssays
Volume45
Issue number8
DOIs
StatePublished - Aug 2023

Keywords

  • cell biology
  • hematopoiesis
  • signal transduction
  • sterile alpha motif
  • transcription

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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