Stimulus-controlled delivery of drugs and genes

David Oupicky; Harender S. Bisht; Devika Soundara Manickam; Qing Hui Zhou

doi:10.1517/17425247.2.4.653

Stimulus-controlled delivery of drugs and genes

David Oupicky, Harender S. Bisht, Devika Soundara Manickam, Qing Hui Zhou

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Macromolecular and colloidal systems used for the systemic delivery of drugs and genes promise to improve the way we treat and prevent numerous diseases. New generations of drug and gene delivery systems (DGDS) are being designed to enhance further efficiency by using a range of endogenous and external stimuli. This review focuses on three qualitatively distinct ways a stimulus can improve the efficiency of DGDS; namely, by selectively triggering release of the therapeutic agent from the DGDS, by modulating physical properties of DGDS and by favourably altering physiological properties of tissues to enhance DGDS transport. Recent developments in these areas are discussed to illustrate the potential of stimulus-controlled DGDS in the development of new generations of therapeutics.

Original language	English (US)
Pages (from-to)	653-665
Number of pages	13
Journal	Expert Opinion on Drug Delivery
Volume	2
Issue number	4
DOIs	https://doi.org/10.1517/17425247.2.4.653
State	Published - Jul 2005
Externally published	Yes

Keywords

Drug delivery
Gene delivery
Heat shock
Hyperthermia
Redox potential gradient
Stimulus
Ultrasound

ASJC Scopus subject areas

Pharmaceutical Science

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10.1517/17425247.2.4.653

Cite this

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abstract = "Macromolecular and colloidal systems used for the systemic delivery of drugs and genes promise to improve the way we treat and prevent numerous diseases. New generations of drug and gene delivery systems (DGDS) are being designed to enhance further efficiency by using a range of endogenous and external stimuli. This review focuses on three qualitatively distinct ways a stimulus can improve the efficiency of DGDS; namely, by selectively triggering release of the therapeutic agent from the DGDS, by modulating physical properties of DGDS and by favourably altering physiological properties of tissues to enhance DGDS transport. Recent developments in these areas are discussed to illustrate the potential of stimulus-controlled DGDS in the development of new generations of therapeutics.",

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AB - Macromolecular and colloidal systems used for the systemic delivery of drugs and genes promise to improve the way we treat and prevent numerous diseases. New generations of drug and gene delivery systems (DGDS) are being designed to enhance further efficiency by using a range of endogenous and external stimuli. This review focuses on three qualitatively distinct ways a stimulus can improve the efficiency of DGDS; namely, by selectively triggering release of the therapeutic agent from the DGDS, by modulating physical properties of DGDS and by favourably altering physiological properties of tissues to enhance DGDS transport. Recent developments in these areas are discussed to illustrate the potential of stimulus-controlled DGDS in the development of new generations of therapeutics.

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KW - Gene delivery

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KW - Redox potential gradient

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KW - Ultrasound

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Stimulus-controlled delivery of drugs and genes

Abstract

Keywords

ASJC Scopus subject areas

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