Stimulus-controlled delivery of drugs and genes

David Oupicky, Harender S. Bisht, Devika Soundara Manickam, Qing Hui Zhou

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Macromolecular and colloidal systems used for the systemic delivery of drugs and genes promise to improve the way we treat and prevent numerous diseases. New generations of drug and gene delivery systems (DGDS) are being designed to enhance further efficiency by using a range of endogenous and external stimuli. This review focuses on three qualitatively distinct ways a stimulus can improve the efficiency of DGDS; namely, by selectively triggering release of the therapeutic agent from the DGDS, by modulating physical properties of DGDS and by favourably altering physiological properties of tissues to enhance DGDS transport. Recent developments in these areas are discussed to illustrate the potential of stimulus-controlled DGDS in the development of new generations of therapeutics.

Original languageEnglish (US)
Pages (from-to)653-665
Number of pages13
JournalExpert Opinion on Drug Delivery
Volume2
Issue number4
DOIs
StatePublished - Jul 2005
Externally publishedYes

Keywords

  • Drug delivery
  • Gene delivery
  • Heat shock
  • Hyperthermia
  • Redox potential gradient
  • Stimulus
  • Ultrasound

ASJC Scopus subject areas

  • Pharmaceutical Science

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