TY - JOUR
T1 - Stimulus-reinforcement-based decision making and anxiety
T2 - Impairment in generalized anxiety disorder (GAD) but not in generalized social phobia (GSP)
AU - DeVido, J.
AU - Jones, M.
AU - Geraci, M.
AU - Hollon, N.
AU - Blair, R. J.R.
AU - Pine, D. S.
AU - Blair, K.
PY - 2009/7
Y1 - 2009/7
N2 - Background. Generalized social phobia (GSP) involves the fear/avoidance of social situations whereas generalized anxiety disorder (GAD) involves an intrusive worry about everyday life circumstances. It remains unclear whether these, highly co-morbid, conditions represent distinct disorders or alternative presentations of a single underlying pathology. In this study, we examined stimulus-reinforcement-based decision making in GSP and GAD. Method. Twenty unmedicated patients with GSP, 16 unmedicated patients with GAD and 19 age-, IQ- and gender-matched healthy comparison (HC) individuals completed the Differential Reward/Punishment Learning Task (DRPLT). In this task, the subject chooses between two objects associated with different levels of reward or punishment. Thus, response choice indexes not only reward/punishment sensitivity but also sensitivity to reward/punishment level according to between-object reinforcement distance. Results. We found that patients with GAD committed a significantly greater number of errors than both the patients with GSP and the HC individuals. By contrast, the patients with GSP and the HC individuals did not differ in performance on this task. Conclusions. These results link GAD with anomalous non-affective-based decision making. They also indicate that GSP and GAD are associated with distinct pathophysiologies.
AB - Background. Generalized social phobia (GSP) involves the fear/avoidance of social situations whereas generalized anxiety disorder (GAD) involves an intrusive worry about everyday life circumstances. It remains unclear whether these, highly co-morbid, conditions represent distinct disorders or alternative presentations of a single underlying pathology. In this study, we examined stimulus-reinforcement-based decision making in GSP and GAD. Method. Twenty unmedicated patients with GSP, 16 unmedicated patients with GAD and 19 age-, IQ- and gender-matched healthy comparison (HC) individuals completed the Differential Reward/Punishment Learning Task (DRPLT). In this task, the subject chooses between two objects associated with different levels of reward or punishment. Thus, response choice indexes not only reward/punishment sensitivity but also sensitivity to reward/punishment level according to between-object reinforcement distance. Results. We found that patients with GAD committed a significantly greater number of errors than both the patients with GSP and the HC individuals. By contrast, the patients with GSP and the HC individuals did not differ in performance on this task. Conclusions. These results link GAD with anomalous non-affective-based decision making. They also indicate that GSP and GAD are associated with distinct pathophysiologies.
KW - Decision making
KW - Generalized anxiety disorder
KW - Generalized social phobia
UR - http://www.scopus.com/inward/record.url?scp=69249232157&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69249232157&partnerID=8YFLogxK
U2 - 10.1017/S003329170800487X
DO - 10.1017/S003329170800487X
M3 - Article
C2 - 19102795
AN - SCOPUS:69249232157
SN - 0033-2917
VL - 39
SP - 1153
EP - 1161
JO - Psychological medicine
JF - Psychological medicine
IS - 7
ER -