Strategies for minimizing immunosuppression in kidney transplantation

Allan D. Kirk, Roslyn B. Mannon, S. John Swanson, Douglas A. Hale

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations

Abstract

Immunosuppression remains the cause of most morbidity following organ transplantation. However, its use is also responsible for the outstanding graft and patient survival rates commonplace in modern transplantation. Thus, the predominant challenge for transplant clinicians is to provide a level of immunosuppression that prevents graft rejection while preserving immunocompetence against environmental pathogens. This review will outline several strategies for minimizing or tailoring the use of immunosuppressive drugs. The arguments for various strategies will be based on clinical trial data rather than animal studies. A distinction will be made between conventional immunosuppressive drug reduction based on over-immunosuppression, and newer induction methods specifically designed to lessen the need for chronic immunosuppression. Based on the available data we suggest that most patients can be transplanted with less immunosuppression than is currently standard.

Original languageEnglish (US)
Pages (from-to)2-14
Number of pages13
JournalTransplant International
Volume18
Issue number1
DOIs
StatePublished - Jan 2005

Keywords

  • Immunosuppression
  • Tolerance
  • Transplant

ASJC Scopus subject areas

  • Transplantation

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