Abstract
Influenza virus has significant viral diversity, both through antigenic drift and shift, which makes development of a vaccine challenging. Current influenza vaccines are updated yearly to include strains predicted to circulate in the upcoming influenza season, however this can lead to a mismatch which reduces vaccine efficacy. Several strategies targeting the most abundant and im-munogenic surface protein of influenza, the hemagglutinin (HA) protein, have been explored. These strategies include stalk-directed, consensus-based, and computationally derived HA immunogens. In this review, we explore vaccine strategies which utilize novel antigen design of the HA protein to improve cross-reactive immunity for development of a universal influenza vaccine.
Original language | English (US) |
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Article number | 257 |
Journal | Vaccines |
Volume | 9 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2021 |
Keywords
- Ancestral
- COBRA
- Centralized
- Chimeric
- Consensus
- Epigraph
- Headless
- Mosaic
- Stalk
- Universal vaccine
ASJC Scopus subject areas
- Immunology
- Pharmacology
- Drug Discovery
- Infectious Diseases
- Pharmacology (medical)