Strategies targeting hemagglutinin as a universal influenza vaccine

Brianna L. Bullard, Eric A. Weaver

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Influenza virus has significant viral diversity, both through antigenic drift and shift, which makes development of a vaccine challenging. Current influenza vaccines are updated yearly to include strains predicted to circulate in the upcoming influenza season, however this can lead to a mismatch which reduces vaccine efficacy. Several strategies targeting the most abundant and im-munogenic surface protein of influenza, the hemagglutinin (HA) protein, have been explored. These strategies include stalk-directed, consensus-based, and computationally derived HA immunogens. In this review, we explore vaccine strategies which utilize novel antigen design of the HA protein to improve cross-reactive immunity for development of a universal influenza vaccine.

Original languageEnglish (US)
Article number257
JournalVaccines
Volume9
Issue number3
DOIs
StatePublished - Mar 2021

Keywords

  • Ancestral
  • COBRA
  • Centralized
  • Chimeric
  • Consensus
  • Epigraph
  • Headless
  • Mosaic
  • Stalk
  • Universal vaccine

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Drug Discovery
  • Infectious Diseases
  • Pharmacology (medical)

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