TY - JOUR
T1 - Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS
AU - Strauss, Jerome F.
AU - Wood, Jennifer R.
AU - Christenson, Lane K.
AU - McAllister, Jan M.
N1 - Funding Information:
Supported by NIH grant HD34449, HD06274, HD07305 and HD33852.
PY - 2002/1/25
Y1 - 2002/1/25
N2 - Polycystic ovary syndrome (PCOS) is characterized by increased ovarian androgen production. We have developed a strategy to identify differentially transcribed genes in PCOS theca cells. Using long-term cultures of normal and PCOS theca cells, we are characterizing the complete repertoire of differentially transcribed genes, the common transcription factor mediators, and the signal transduction cascade(s) that are abnormal in PCOS theca cells. The latter will be interrogated for mutations/genetic variants linked to PCOS.
AB - Polycystic ovary syndrome (PCOS) is characterized by increased ovarian androgen production. We have developed a strategy to identify differentially transcribed genes in PCOS theca cells. Using long-term cultures of normal and PCOS theca cells, we are characterizing the complete repertoire of differentially transcribed genes, the common transcription factor mediators, and the signal transduction cascade(s) that are abnormal in PCOS theca cells. The latter will be interrogated for mutations/genetic variants linked to PCOS.
KW - Androgen biosynthesis
KW - Chromatin immunoprecipitation
KW - Polycystic ovary syndrome
KW - Suppression subtractive hybridization
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U2 - 10.1016/S0303-7207(01)00662-1
DO - 10.1016/S0303-7207(01)00662-1
M3 - Article
C2 - 11900894
AN - SCOPUS:0037168920
VL - 186
SP - 183
EP - 188
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - 2
ER -