Abstract
Polycystic ovary syndrome (PCOS) is characterized by increased ovarian androgen production. We have developed a strategy to identify differentially transcribed genes in PCOS theca cells. Using long-term cultures of normal and PCOS theca cells, we are characterizing the complete repertoire of differentially transcribed genes, the common transcription factor mediators, and the signal transduction cascade(s) that are abnormal in PCOS theca cells. The latter will be interrogated for mutations/genetic variants linked to PCOS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 183-188 |
| Number of pages | 6 |
| Journal | Molecular and Cellular Endocrinology |
| Volume | 186 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 25 2002 |
Keywords
- Androgen biosynthesis
- Chromatin immunoprecipitation
- Polycystic ovary syndrome
- Suppression subtractive hybridization
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Endocrinology
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Strauss, J. F., Wood, J. R., Christenson, L. K., & McAllister, J. M. (2002). Strategies to elucidate the mechanism of excessive theca cell androgen production in PCOS. Molecular and Cellular Endocrinology, 186(2), 183-188. https://doi.org/10.1016/S0303-7207(01)00662-1