Structural analysis of chloroquine resistance reversal by imipramine analogs

A. K. Bhattacharjee, D. E. Kyle, J. L. Vennerstrom

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

For imipramine, desipramine, and eight analogs of these well-known drugs, an N-5-aminoalkyl substitution was a minimum but insufficient structural feature associated with chloroquine resistance reversal. Although a second distal aliphatic nitrogen atom was unnecessary for resistance reversal, the direction of the dipole moment vector was critical.

Original languageEnglish (US)
Pages (from-to)2655-2657
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number9
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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