Structural and Mechanical Properties of Human Superficial Femoral and Popliteal Arteries

Ramin Shahbad, Margarita Pipinos, Majid Jadidi, Anastasia Desyatova, Jennifer Gamache, Jason MacTaggart, Alexey Kamenskiy

Research output: Contribution to journalReview articlepeer-review


The femoropopliteal artery (FPA) is the main artery in the lower limb. It supplies blood to the leg muscles and undergoes complex deformations during limb flexion. Atherosclerotic disease of the FPA (peripheral arterial disease, PAD) is a major public health burden, and despite advances in surgical and interventional therapies, the clinical outcomes of PAD repairs continue to be suboptimal, particularly in challenging calcified lesions and biomechanically active locations. A better understanding of human FPA mechanical and structural characteristics in relation to age, risk factors, and the severity of vascular disease can help develop more effective and longer-lasting treatments through computational modeling and device optimization. This review aims to summarize recent research on the main biomechanical and structural properties of human superficial femoral and popliteal arteries that comprise the FPA and describe their anatomy, composition, and mechanical behavior under different conditions.

Original languageEnglish (US)
Pages (from-to)794-815
Number of pages22
JournalAnnals of biomedical engineering
Issue number4
StatePublished - Apr 2024


  • Aging
  • Computational modeling
  • Femoropopliteal artery
  • Mechanical properties
  • Structure

ASJC Scopus subject areas

  • Biomedical Engineering


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