Structural constraints from proton-mediated rare-spin correlation spectroscopy in rotating solids

Adam Lange, Sorin Luca, Marc Baldus

Research output: Contribution to journalArticle

203 Scopus citations

Abstract

A novel solid-state NMR concept is introduced that allows for the detection of through-space proton-proton contacts in high spectral resolution. The proposed method not only can be utilized to infer sequential assignments and backbone or side chain conformation in solid-phase polypeptides, but it also provides information about the three-dimensional arrangement of the molecule of interest. As a result, the molecular structure can be studied without additional restrictions regarding sample labeling or magic angle spinning rates.

Original languageEnglish (US)
Pages (from-to)9704-9705
Number of pages2
JournalJournal of the American Chemical Society
Volume124
Issue number33
DOIs
StatePublished - Aug 21 2002

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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