Structural Insight into a Fatty-Acyl Chaperone for Wnt Proteins

Mark A. Wilson

doi:10.1016/j.str.2017.11.009

Structural Insight into a Fatty-Acyl Chaperone for Wnt Proteins

Mark A. Wilson

Biochemistry

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

Wnt signaling proteins are fatty-acylated and bind to the protein afamin. The afamin-Wnt complex increases Wnt solubility dramatically and is likely involved in Wnt trafficking. In this issue of Structure, Naschberger et al. (2017) determine the crystal structure of afamin in complex with palmitoleic acid, revealing how afamin binds palmitoleoylated Wnt. Wnt signaling proteins are fatty-acylated and bind to the protein afamin. The afamin-Wnt complex increases Wnt solubility dramatically and is likely involved in Wnt trafficking. In this issue of Structure, Naschberger et al. (2017) determine the crystal structure of afamin in complex with palmitoleic acid, revealing how afamin binds palmitoleoylated Wnt.

Original language	English (US)
Pages (from-to)	1781-1782
Number of pages	2
Journal	Structure
Volume	25
Issue number	12
DOIs	https://doi.org/10.1016/j.str.2017.11.009
State	Published - Dec 5 2017

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1016/j.str.2017.11.009

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abstract = "Wnt signaling proteins are fatty-acylated and bind to the protein afamin. The afamin-Wnt complex increases Wnt solubility dramatically and is likely involved in Wnt trafficking. In this issue of Structure, Naschberger et al. (2017) determine the crystal structure of afamin in complex with palmitoleic acid, revealing how afamin binds palmitoleoylated Wnt. Wnt signaling proteins are fatty-acylated and bind to the protein afamin. The afamin-Wnt complex increases Wnt solubility dramatically and is likely involved in Wnt trafficking. In this issue of Structure, Naschberger et al. (2017) determine the crystal structure of afamin in complex with palmitoleic acid, revealing how afamin binds palmitoleoylated Wnt.",

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AB - Wnt signaling proteins are fatty-acylated and bind to the protein afamin. The afamin-Wnt complex increases Wnt solubility dramatically and is likely involved in Wnt trafficking. In this issue of Structure, Naschberger et al. (2017) determine the crystal structure of afamin in complex with palmitoleic acid, revealing how afamin binds palmitoleoylated Wnt. Wnt signaling proteins are fatty-acylated and bind to the protein afamin. The afamin-Wnt complex increases Wnt solubility dramatically and is likely involved in Wnt trafficking. In this issue of Structure, Naschberger et al. (2017) determine the crystal structure of afamin in complex with palmitoleic acid, revealing how afamin binds palmitoleoylated Wnt.

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Structural Insight into a Fatty-Acyl Chaperone for Wnt Proteins

Abstract

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