Structural Insight into a Fatty-Acyl Chaperone for Wnt Proteins

Mark A. Wilson

Research output: Contribution to journalShort surveypeer-review

4 Scopus citations

Abstract

Wnt signaling proteins are fatty-acylated and bind to the protein afamin. The afamin-Wnt complex increases Wnt solubility dramatically and is likely involved in Wnt trafficking. In this issue of Structure, Naschberger et al. (2017) determine the crystal structure of afamin in complex with palmitoleic acid, revealing how afamin binds palmitoleoylated Wnt. Wnt signaling proteins are fatty-acylated and bind to the protein afamin. The afamin-Wnt complex increases Wnt solubility dramatically and is likely involved in Wnt trafficking. In this issue of Structure, Naschberger et al. (2017) determine the crystal structure of afamin in complex with palmitoleic acid, revealing how afamin binds palmitoleoylated Wnt.

Original languageEnglish (US)
Pages (from-to)1781-1782
Number of pages2
JournalStructure
Volume25
Issue number12
DOIs
StatePublished - Dec 5 2017

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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