Structure-activity studies of aldose reductase inhibitors containing the 4-oxo-4H-chromen ring system

Peter F. Kador; Norman E. Sharpless

doi:10.1016/0301-4622(78)85025-X

Structure-activity studies of aldose reductase inhibitors containing the 4-oxo-4H-chromen ring system

Peter F. Kador, Norman E. Sharpless

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Abstract

Various 4-oxo-4H-chromen-2-carboxylic acids and their derivatives were screened for aldose reductase inhibitory activity. Their inhibitory response along with that of several flavonoids has been correlated with simple Hückel molecular orbital calculations. From these results a possible mode of action is postulated.

Original language	English (US)
Pages (from-to)	81-85
Number of pages	5
Journal	Biophysical Chemistry
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/0301-4622(78)85025-X
State	Published - Mar 1978

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ASJC Scopus subject areas

Biophysics
Biochemistry
Organic Chemistry

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Kador, P. F., & Sharpless, N. E. (1978). Structure-activity studies of aldose reductase inhibitors containing the 4-oxo-4H-chromen ring system. Biophysical Chemistry, 8(1), 81-85. https://doi.org/10.1016/0301-4622(78)85025-X

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Access to Document

10.1016/0301-4622(78)85025-X