Structure-activity studies of aldose reductase inhibitors containing the 4-oxo-4H-chromen ring system

Peter F. Kador, Norman E. Sharpless

Research output: Contribution to journalArticle

56 Scopus citations


Various 4-oxo-4H-chromen-2-carboxylic acids and their derivatives were screened for aldose reductase inhibitory activity. Their inhibitory response along with that of several flavonoids has been correlated with simple Hückel molecular orbital calculations. From these results a possible mode of action is postulated.

Original languageEnglish (US)
Pages (from-to)81-85
Number of pages5
JournalBiophysical Chemistry
Issue number1
StatePublished - Mar 1978


ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Organic Chemistry

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