Structure-activity studies of aldose reductase inhibitors containing the 4-oxo-4H-chromen ring system

Peter F. Kador; Norman E. Sharpless

doi:10.1016/0301-4622(78)85025-X

Structure-activity studies of aldose reductase inhibitors containing the 4-oxo-4H-chromen ring system

Peter F. Kador, Norman E. Sharpless

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Various 4-oxo-4H-chromen-2-carboxylic acids and their derivatives were screened for aldose reductase inhibitory activity. Their inhibitory response along with that of several flavonoids has been correlated with simple Hückel molecular orbital calculations. From these results a possible mode of action is postulated.

Original language	English (US)
Pages (from-to)	81-85
Number of pages	5
Journal	Biophysical Chemistry
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/0301-4622(78)85025-X
State	Published - Mar 1978
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Organic Chemistry

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10.1016/0301-4622(78)85025-X

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title = "Structure-activity studies of aldose reductase inhibitors containing the 4-oxo-4H-chromen ring system",

abstract = "Various 4-oxo-4H-chromen-2-carboxylic acids and their derivatives were screened for aldose reductase inhibitory activity. Their inhibitory response along with that of several flavonoids has been correlated with simple H{\"u}ckel molecular orbital calculations. From these results a possible mode of action is postulated.",

author = "Kador, {Peter F.} and Sharpless, {Norman E.}",

year = "1978",

month = mar,

doi = "10.1016/0301-4622(78)85025-X",

language = "English (US)",

volume = "8",

pages = "81--85",

journal = "Biophysical Chemistry",

issn = "0301-4622",

publisher = "Elsevier B.V.",

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T1 - Structure-activity studies of aldose reductase inhibitors containing the 4-oxo-4H-chromen ring system

AU - Kador, Peter F.

AU - Sharpless, Norman E.

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N2 - Various 4-oxo-4H-chromen-2-carboxylic acids and their derivatives were screened for aldose reductase inhibitory activity. Their inhibitory response along with that of several flavonoids has been correlated with simple Hückel molecular orbital calculations. From these results a possible mode of action is postulated.

AB - Various 4-oxo-4H-chromen-2-carboxylic acids and their derivatives were screened for aldose reductase inhibitory activity. Their inhibitory response along with that of several flavonoids has been correlated with simple Hückel molecular orbital calculations. From these results a possible mode of action is postulated.

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U2 - 10.1016/0301-4622(78)85025-X

DO - 10.1016/0301-4622(78)85025-X

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AN - SCOPUS:0017894486

SN - 0301-4622

VL - 8

SP - 81

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JO - Biophysical Chemistry

JF - Biophysical Chemistry

IS - 1

ER -

Structure-activity studies of aldose reductase inhibitors containing the 4-oxo-4H-chromen ring system

Abstract

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