Abstract
Various 4-oxo-4H-chromen-2-carboxylic acids and their derivatives were screened for aldose reductase inhibitory activity. Their inhibitory response along with that of several flavonoids has been correlated with simple Hückel molecular orbital calculations. From these results a possible mode of action is postulated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 81-85 |
| Number of pages | 5 |
| Journal | Biophysical Chemistry |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 1978 |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Organic Chemistry
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Cite this
Kador, P. F., & Sharpless, N. E. (1978). Structure-activity studies of aldose reductase inhibitors containing the 4-oxo-4H-chromen ring system. Biophysical Chemistry, 8(1), 81-85. https://doi.org/10.1016/0301-4622(78)85025-X