Structure and function of eukaryotic DNA polymerase δ

Tahir H. Tahirov

doi:10.1007/978-94-007-4572-8_12

Structure and function of eukaryotic DNA polymerase δ

Tahir H. Tahirov

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

DNA polymerase d (Pol δ) is a member of the B-family DNA polymerases and is one of the major replicative DNA polymerases in eukaryotes. In addition to chromosomal DNA replication it is also involved in DNA repair and recombination. Pol δ is a multi-subunit complex comprised of a catalytic subunit and accessory subunits. The latter subunits play a critical role in the regulation of Pol δ functions. Recent progress in the structural characterization of Pol δ, together with a vast number of biochemical and functional studies, provides the basis for understanding the intriguing mechanisms of its regulation during DNA replication, repair and recombination. In this chapter we review the current state of the Pol δ structure-function relationship with an emphasis on the role of its accessory subunits.

Original language	English (US)
Pages (from-to)	217-236
Number of pages	20
Journal	Sub-cellular biochemistry
Volume	62
DOIs	https://doi.org/10.1007/978-94-007-4572-8_12
State	Published - 2012

Keywords

Accessory subunits
Catalytic subunit
Crystal structure
DNA polymerase delta
Iron-sulfur cluster

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology
Cancer Research

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10.1007/978-94-007-4572-8_12

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abstract = "DNA polymerase d (Pol δ) is a member of the B-family DNA polymerases and is one of the major replicative DNA polymerases in eukaryotes. In addition to chromosomal DNA replication it is also involved in DNA repair and recombination. Pol δ is a multi-subunit complex comprised of a catalytic subunit and accessory subunits. The latter subunits play a critical role in the regulation of Pol δ functions. Recent progress in the structural characterization of Pol δ, together with a vast number of biochemical and functional studies, provides the basis for understanding the intriguing mechanisms of its regulation during DNA replication, repair and recombination. In this chapter we review the current state of the Pol δ structure-function relationship with an emphasis on the role of its accessory subunits.",

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AB - DNA polymerase d (Pol δ) is a member of the B-family DNA polymerases and is one of the major replicative DNA polymerases in eukaryotes. In addition to chromosomal DNA replication it is also involved in DNA repair and recombination. Pol δ is a multi-subunit complex comprised of a catalytic subunit and accessory subunits. The latter subunits play a critical role in the regulation of Pol δ functions. Recent progress in the structural characterization of Pol δ, together with a vast number of biochemical and functional studies, provides the basis for understanding the intriguing mechanisms of its regulation during DNA replication, repair and recombination. In this chapter we review the current state of the Pol δ structure-function relationship with an emphasis on the role of its accessory subunits.

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KW - Catalytic subunit

KW - Crystal structure

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KW - Iron-sulfur cluster

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Structure and function of eukaryotic DNA polymerase δ

Abstract

Keywords

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