Structure and function of eukaryotic DNA polymerase δ

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17 Scopus citations

Abstract

DNA polymerase d (Pol δ) is a member of the B-family DNA polymerases and is one of the major replicative DNA polymerases in eukaryotes. In addition to chromosomal DNA replication it is also involved in DNA repair and recombination. Pol δ is a multi-subunit complex comprised of a catalytic subunit and accessory subunits. The latter subunits play a critical role in the regulation of Pol δ functions. Recent progress in the structural characterization of Pol δ, together with a vast number of biochemical and functional studies, provides the basis for understanding the intriguing mechanisms of its regulation during DNA replication, repair and recombination. In this chapter we review the current state of the Pol δ structure-function relationship with an emphasis on the role of its accessory subunits.

Original languageEnglish (US)
Pages (from-to)217-236
Number of pages20
JournalSub-cellular biochemistry
Volume62
DOIs
StatePublished - 2012

Keywords

  • Accessory subunits
  • Catalytic subunit
  • Crystal structure
  • DNA polymerase delta
  • Iron-sulfur cluster

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology
  • Cancer Research

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