Structure and function of IRF-7

Luwen Zhang, Joseph S. Pagano

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations


Interferon (IFN) regulatory factors (IRF) are a family of transcription factors with multiple functions. IRF-7 was initially cloned within the biologic context of Epstein-Barr virus (EBV) latency and discovered to have an intimate relation with the EBV primary oncogenic protein, latent membrane protein-1 (LMP-1). EBV regulates and uses IRF-7 as a secondary mediator for several target genes involved in latency and immune regulation. Other than its functions in EBV latency, IRF-7 has been identified as one of the major players in virally induced IFN production that is central to innate immunity. Thus, IRF-7 plays important roles in a variety of biologic systems.

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalJournal of Interferon and Cytokine Research
Issue number1
StatePublished - 2002

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Virology


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