Structure-function analysis of CCL28 in the development of post-viral asthma

Monica A. Thomas, Becky J. Buelow, Amanda M. Nevins, Stephanie E. Jones, Francis C. Peterson, Rebekah L. Gundry, Mitchell H. Grayson, Brian F. Volkman

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Background: CCL28 is associated with the pathogenesis of acute post-viral asthma. Results: In the absence of viral infection, natively folded CCL28 can induce asthma pathology, whereas unfolded CCL28 cannot. Conclusion: The structure of CCL28 is critical for its role in asthma pathogenesis. Significance: Inhibition of CCL28 presents a novel therapeutic option for the prevention of post-viral asthma.

Original languageEnglish (US)
Pages (from-to)4528-4536
Number of pages9
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
StatePublished - Feb 13 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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