Structure-function analysis of CCL28 in the development of post-viral asthma

Monica A. Thomas; Becky J. Buelow; Amanda M. Nevins; Stephanie E. Jones; Francis C. Peterson; Rebekah L. Gundry; Mitchell H. Grayson; Brian F. Volkman

doi:10.1074/jbc.M114.627786

Structure-function analysis of CCL28 in the development of post-viral asthma

Monica A. Thomas, Becky J. Buelow, Amanda M. Nevins, Stephanie E. Jones, Francis C. Peterson, Rebekah L. Gundry, Mitchell H. Grayson, Brian F. Volkman

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background: CCL28 is associated with the pathogenesis of acute post-viral asthma. Results: In the absence of viral infection, natively folded CCL28 can induce asthma pathology, whereas unfolded CCL28 cannot. Conclusion: The structure of CCL28 is critical for its role in asthma pathogenesis. Significance: Inhibition of CCL28 presents a novel therapeutic option for the prevention of post-viral asthma.

Original language	English (US)
Pages (from-to)	4528-4536
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	290
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M114.627786
State	Published - Feb 13 2015
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Structure-function analysis of CCL28 in the development of post-viral asthma",

abstract = "Background: CCL28 is associated with the pathogenesis of acute post-viral asthma. Results: In the absence of viral infection, natively folded CCL28 can induce asthma pathology, whereas unfolded CCL28 cannot. Conclusion: The structure of CCL28 is critical for its role in asthma pathogenesis. Significance: Inhibition of CCL28 presents a novel therapeutic option for the prevention of post-viral asthma.",

author = "Thomas, {Monica A.} and Buelow, {Becky J.} and Nevins, {Amanda M.} and Jones, {Stephanie E.} and Peterson, {Francis C.} and Gundry, {Rebekah L.} and Grayson, {Mitchell H.} and Volkman, {Brian F.}",

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doi = "10.1074/jbc.M114.627786",

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T1 - Structure-function analysis of CCL28 in the development of post-viral asthma

AU - Thomas, Monica A.

AU - Buelow, Becky J.

AU - Nevins, Amanda M.

AU - Jones, Stephanie E.

AU - Peterson, Francis C.

AU - Gundry, Rebekah L.

AU - Grayson, Mitchell H.

AU - Volkman, Brian F.

PY - 2015/2/13

Y1 - 2015/2/13

N2 - Background: CCL28 is associated with the pathogenesis of acute post-viral asthma. Results: In the absence of viral infection, natively folded CCL28 can induce asthma pathology, whereas unfolded CCL28 cannot. Conclusion: The structure of CCL28 is critical for its role in asthma pathogenesis. Significance: Inhibition of CCL28 presents a novel therapeutic option for the prevention of post-viral asthma.

AB - Background: CCL28 is associated with the pathogenesis of acute post-viral asthma. Results: In the absence of viral infection, natively folded CCL28 can induce asthma pathology, whereas unfolded CCL28 cannot. Conclusion: The structure of CCL28 is critical for its role in asthma pathogenesis. Significance: Inhibition of CCL28 presents a novel therapeutic option for the prevention of post-viral asthma.

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JO - Journal of Biological Chemistry

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Structure-function analysis of CCL28 in the development of post-viral asthma

Abstract

ASJC Scopus subject areas

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