Structure, function and metabolism of hepatic and adipose tissue lipid droplets: Implications in alcoholic liver disease

Sathish K Natarajan, Karuna Rasineni, Murali Ganesan, Dan Feng, Benita L McVicker, Mark A. McNiven, Natalia A Osna, Justin L Mott, Carol A Casey, Kusum Kharbanda

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

For more than 30 years, lipid droplets (LDs) were considered as an inert bag of lipid for storage of energy-rich fat molecules. Following a paradigm shift almost a decade ago, LDs are presently considered an active subcellular organelle especially designed for assembling, storing and subsequently supplying lipids for generating energy and membrane synthesis (and in the case of hepatocytes for VLDL secretion). LDs also play a central role in many other cellular functions such as viral assembly and protein degradation. Here, we have explored the structural and functional changes that occur in hepatic and adipose tissue LDs following chronic ethanol consumption in relation to their role in the pathogenesis of alcoholic liver injury.

Original languageEnglish (US)
Pages (from-to)237-248
Number of pages12
JournalCurrent Molecular Pharmacology
Volume10
Issue number3
DOIs
StatePublished - Aug 1 2017

Keywords

  • ATGL
  • Adipose
  • Alcohol
  • Betaine
  • Dynamin
  • HCV
  • HSL
  • Lipases
  • Lipid
  • Lipid droplet
  • Lipolysis
  • Lipophagy
  • Liver
  • MiRs
  • Perilipin
  • Phosphatidylcholine
  • Phosphatidylethanolamine
  • Rab
  • Src
  • Steatosis
  • TGH
  • Triglycerides
  • VLDL

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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